TIME is proud to provide trusted information about health from the leaders at the forefront of game-changing innovations, including members of the TIME100 Health list of the world’s most influential people in health in 2024. Last week, at TIME HQ in NYC, we hosted a TIME100 Talks

Our work led by Megan Buckley on Saturation Genome Editing of VHL is now out in Nature Genetics: nature.com/articles/s4158… Many new experiments and analyses to quickly highlight… (1/n)

🚨 An atmosphere on a super-Earth in the habitable zone? 🔎🌍🔭 We're excited to share our new NASA Webb Telescope observations of the super-Earth LHS 1140b. THREAD

Today we report in Nature Biomedical Engineering the systematic application of six recent prime editing developments to enable efficient and functional correction of CFTR F508del, the predominant mutation that causes cystic fibrosis (CF), in primary airway cells from CF patients.

I think of Mila Vitarello Mila's Miracle when I read this and how her mom, Julia, speaks about the what-if of earlier access for Mila. The central goal of the next 5 yrs is to platformize such cures, ASO and CRISPR, and deliver them to patients in that mode. endpts.com/a-teenager-fac…

"CRISPR as a standard of medical care" - this is the Innovative Genomics Institute mission as set by our founder, Jennifer Doudna. Dr Melinda Kliegman, our Director of Public Impact, led an extraordinary KOL task force to develop actionable solutions to the key challenge of affordability.

Directed evolution is key for unlocking new protein function But is difficult and time consuming So how can we accelerate protein design by 10-100x? With AI! Now introducing EVOLVEpro, an LLM-based model for evolving proteins rapidly and efficiently biorxiv.org/content/10.110…

I'm scrolling through this saying to myself - "wait, where are the editors already?!?" and then - bam, there's Vijay Sankaran and there's Sam Sternberg!!! Yay both!!! hhmi.org/news/hhmi-inve…

A Disease That Makes Children Age Rapidly Gets Closer to a Cure nytimes.com/2024/07/24/hea… via Gina Kolata The New York Times

Deeply honored to receive the 2024 Foundation for the National Institutes of Health Trailblazer Prize! Heartfelt thanks to the incredible lab members past and present, generous mentors, fantastic collaborators, inspiring patients/families, and others who made this possible! 🙏 to my nominator, the amazing Aviv Regev!

I'm a little late to the party, but glad to share that our manuscript describing click editing has been published in Nature Biotechnology. An amazing team effort led by Joana Ferreira da Silva Connor Tou & others. CGM at MGH Mass General Research Institute Harvard Medical School #clickediting 🧬 nature.com/articles/s4158…

Madoff died in jail. Holmes and Balwani ARE in jail. Their fellow persona non grata - as legitimate a "gene editor" as Madoff an investor - has been ostracized. Stay on the other shore of Styx where you belong, He(rostratus). 🙏 Megan Molteni statnews.com/2024/07/24/jia…

From Adam Potter, MD, PhD, FACC + Christina Miyake + Xander Wehrens + team: Rare Variant in MRC2 Associated With Familial Supraventricular Tachycardia and Wolff-Parkinson-White Syndrome ahajournals.org/doi/abs/10.116… AHA Science #AHAjournals #CardioTwitter #Genetics BCM_CVRI 🎥H.J. Tadros

A bespoke genetic therapy is helping Susannah. Can similar drugs be made at scale for other rare diseases? statnews.com/2024/08/09/rar… via Jonathan Wosen, Ph.D. STAT

Dr Klug discovered the C2H2 zinc finger and invented a way for their engineering as the basis for genome and epigenome editing (11433278). He should be by every objective criterion called a founding parent of both.

Epigenome editing as a therapeutic?.. To explain I offer an analogy to musical harmony: whether in Taylor Swift's "Love Story" or Franz Schubert's "Song of Love," it's what makes music sound right. Epiediting aims to restore gene expression harmony. TIME time.com/7009555/700955…

Very humbled by this award, which has gone to some of my favorite science writers over the years. And thankful to all the sources — parents, advocates, scientists — who gave parts of their very scarce time for these pieces

Nice story on the emergence of University City as the epicenter of #celltherapy & #genetherapy #CelliconValley #Philly City Journal Charles McElwee city-journal.org/article/philad…

Is there room for human #CRISPR gene editing beyond treating existing disease? We need answers soon based on progress in the field. Antonio Regalado's piece provides serious food for thought here. Read and feel your heart rate rise - in a good way. technologyreview.com/2024/08/22/109…

The full evolution of today’s mesmerising #SolarFlare, which continued for over 12 hours! This is a very long duration event, as most flares are over well within an hour of onset. Just look at those flare loops grow! Awe-some stuff. #spaceweather #astronomy