Immunohistochemical staining with Glyoxal as Fixative 9% Glyoxal/8% acetic acid No antigen retrieval needed PBS+ 0.1% Triton X-100 vs Formaldehyde fixation ▶️⏫immunostaining intensity ▶️Make FFPE-incompatible antibodies useful Working on paraffin section, ultrathin resin

Science at its best, unexpected discovery which sends you back to the drawing board nature.com/articles/s4158…

A paper in nature reports the ageing effects of a pro-inflammatory protein called IL11 in mice. Inhibition of this protein is shown to improve the health of old mice and increase their lifespan. go.nature.com/3WqC0JX

Levels of gene expression matter! So how can you control a transgene precisely? Is there a tool that can ensure uniform control & the ability to adjust the setpoint of expression from a single promoter? Introducing DIAL! 🧵 (1/n) Link: doi.org/10.1101/2024.0…

And it’s out! Our lab’s very first paper is published today Nature Methods! Our calcium-activated split-TurboID (CaST) can biochemically tag activated neurons within 10 minutes, enabling a molecular handle on functionally relevant cell ensembles: tinyurl.com/ddyecxze

How do different neuronal populations and compartments determine molecular and synaptic diversity? Check out our collaborative effort for parallel transcriptomic and proteomic profiling of the hippocampus! Erin schuman Lab at MPI for Brain Research bioRxiv Neuroscience

Delighted to see our work out in eLife - the journal with very thoughtful comments from reviewers! "Early-life stress induces persistent astrocyte dysfunction resulting in fear generalisation" doi.org/10.7554/eLife.…

Our new study is out today in the New England Journal of Medicine! We demonstrate a speech neuroprosthesis that decodes the attempted speech of a man with ALS into text with 97.5% accuracy, enabling him to communicate with his family, friends, and colleagues in his own home. 1/9

Very proud of this important work on how thyroid status impacts the brain and behavior. Led by postdoc Dan Hochbaum who assembled quite a team urldefense.proofpoint.com/v2/url?u=https…

Know your neighbours…🏘️ Spatial positioning determines tissue-resident memory T cell fate in the gut. Marina Schernthanner covers work from Alex Monell Miguel Reina-Campos Maximilian Heeg Goldrath Lab John Chang Gene Yeo’s Lab at UC San Diego et al. #preprint #preLight ⬇️ 👀 prelights.biologists.com/highlights/fun…

Search: Tenure track Faculty Position UC San Francisco in the Dept. of Micro and Immuno, with lab space at the Mission Bay campus! We seek a creative investigator with a strong independent research plan who will be a great mentor, colleague, and peer. Job ad soon. Assistant Prof level.

In vivo evidence that failed pathogens, resulting from infidelities in infection strategies, are the drivers of innate immunity. Krause and Cepko discovered that in the brain, non-productively infected cells are the source of interferon. pnas.org/doi/epub/10.10…

Our new paper is out nature We report that fibrin drives toxic inflammation, impaired viral clearance & neuropathology in #SARSCoV2 infection treated by #fibrin antibody #LongCovid #Coagulation #Immunotherapy #fibrinogen #COVID19 nature.com/articles/s4158…

Characteristics of blood–brain barrier heterogeneity between brain regions revealed by profiling vascular and perivascular cells Nature Neuroscience nature.com/articles/s4159…

Excited to be part of the Bioinformatics and Systems Biology PhD program at UC San Diego - Using Spatial Omics in immunology research requires a new combination of computational, imaging, and wet lab skills - we need YOU! Please reach out

🚨UVa Neurodegeneration job alert!! UVa Neuroscience is hiring multiple TT faculty in neurodegenerative disease research. If you're looking for a vibrant scientific community with wonderful colleagues then check it out! Please share/rt! UVA Research BIG_UVA UVA Neurology

🌿🔬 In the latest Beyond Lab Walls podcast episode, host Nicole Mlynaryk Nicole Mlynaryk chats with postdoc Lara Labarta-Bajo Lara Labarta-Bajo, PhD about how our immune system and brain communicate as we age. Discover how astrocytes could hold the key to healthy aging! 🎧 Tune in now!

5 years ago, on the heels of 28andMe, our team designed a new precision imaging experiment: scanning an individual’s brain throughout her entire pregnancy. We are excited to share that these findings are out today in Nature Neuroscience! nature.com/articles/s4159…

Regions of the human brain may shrink in size during pregnancy, but have better connectivity, with only a few regions of the brain remaining untouched by the transition to motherhood, according to research published in Nature Neuroscience. go.nature.com/4enUvov

💥Salk Institute Job Posting Alert💥 Seeking Assistant Professors pioneering innovative research in immunology and inflammation—areas like neuro-immunology, cancer immunology, virology, and more. Join our collaborative team at the NOMIS Center! 🔬 Outstanding start-up package 🌟