Scientists at Lurie Cancer Center have discovered new insights into noncoding #RNAs and how changes in their signatures diversify and modulate the transcriptome of three types of cancer, per findings from Lauberth Lab in Science Advances. news.feinberg.northwestern.edu/2024/08/01/stu… #bcsm #crcsm

A team of investigators led by Michael DeCuypere MD, PhD& Amy Heimberger, MD discovered that targeting a protein called TIM3 may increase survival in pediatric #BrainCancers compared to current immunotherapies, published in Journal of Clinical Investigation:news.feinberg.northwestern.edu/2024/08/19/inv…. Northwestern Feinberg School of Medicine Lurie Cancer Center

Lurie Cancer Center scientists at Northwestern Medicine have developed a new, more precise method to target proteins implicated in certain types of #cancer, according to a study published in Nature Chemical Biology. news.feinberg.northwestern.edu/2024/07/26/dev… via Northwestern Feinberg School of Medicine #TPD

Hijacking (E3 ligase) FBXO22 for targeted protein degradation "may present a promising approach for targeting cancer cells while potentially reducing toxicity in normal cells," said Xiaoyu Zhang, PhD, Xiaoyu Zhang, the study's senior author and a member of Lurie Cancer Center.

A new paper from @Lauberthlab by Mannan Bhola and Kouki Abe shows how RNA and TOP1 work together to regulate DNA topological stress during transcription Molecular Cell. It was a pleasure working with the Mondragon, Eric Van Nostrand , John F Marko , and He labs. authors.elsevier.com/a/1jd-m3vVUPRm…

Northwestern Medicine investigators have uncovered a new way in which #neurons in the brain “forget” associations that help guide #behavior and habits, per CellReports. spr.ly/6016lNZ3r

Confession - we don't just work on ion channels. Shocking I know. See evidence of this on bioRxiv now. Great to collaborate with KearneyLab to model alternating hemiplegia of childhood in mice. #ahcawareness biorxiv.org/content/10.110…

A new #BioactiveMaterial developed by Northwestern scientists may be able to regenerate high-quality #cartilage in knee joints. spr.ly/6018mPsHe

The NIH recently funded the SILOS Project, led by principal investigator @MichelleBirkett, PhD, which will conduct observational research across five cities across to understand better the social contexts that drive #HIV and substance use. 🔗 spr.ly/6017mkPeb

Nearly 20 percent of suicides in Illinois between 2020 and 2021 were among people 65 years and older, according to recently released data. spr.ly/6016mjoOG

The NUCATS Institute has received $55 million in NIH funding to accelerate the development, evaluation, and implementation of improved #HealthcareInterventions. spr.ly/6012mgNhQ

An international team has found that non-neuron brain cells called #oligodendrocytes, along with neurons, contribute to around one-third of plaque formation in mouse models of Alzheimer’s disease, per Nature Neuroscience. Mesulam Center at Northwestern spr.ly/6014mmW88

I joined Northwestern Feinberg School of Medicine in 2022 because of the institutional support and enthusiasm for #impsci. Now, I am honored to share that #imspci is 1 of 3 strategic pillars of NUCATS Institute, creating an unprecedented opportunity to advance inclusive, innovative, implementable research

Scientists have found that pediatricians are more likely to have conversations with parents about #GunSafety and secure storage if they receive a “nudge” from an electronic health record, per JAMA Pediatrics. spr.ly/6016m7VBK

I am thrilled to share National Institute of Mental Health (NIMH) ASPIRE trial results JAMA Pediatrics. Bottom line: An EHR strategy + clinic support resulted in 49% reach of an evidence-based secure firearm storage program in pediatrics (compared to 22% in EHR strategy alone; 2% in usual care). jamanetwork.com/journals/jamap…

Love this egg-squisite CODEX image of an ovary made by #HuBMAP Human BioMolecular Atlas Program (HuBMAP) researchers Elizabeth Tsui, Hannah McDowell (Laronda lab Northwestern Feinberg School of Medicine), Alex Cabrera & Jean Rosario (O’Neill lab Penn Medicine)! It will send you ovary the rainbow! #WomenInScience #PCOSAwarenessMonth2024