LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade biorxiv.org/content/10.110…

doi.org/10.7554/eLife.… eLife - the journal So excited to share our functional studies of NPC1 and NPC1L1 cholesterol transporters! @stanfordbiochemistry

#Parkinsons michaeljfox.org Aligning Science Across Parkinson’s Stanford Biochemistry Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain biorxiv.org/content/10.110…

Fantastic Aligning Science Across Parkinson’s Supergroup Meeting of Alessi-De Camilli teams MRC PPU De Camilli Lab. Beautiful data from Pietro De Camilli Suzanne Pfeffer Shawn Ferguson Monther Abu-Remaileh #cellbiology #organelle biology #Parkinsons Looking forward to the next one!

LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade life-science-alliance.org/content/4/5/e2… michaeljfox.org

We're looking for a postdoc to join our projects on the biochemistry and cell biology of LRRK2-Rab GTPase phosphorylation in ciliogenesis and Parkinson's disease at Stanford University. pfeffer.stanford.edu Please RT! jobs.ascb.org/jobs/

Ji Sun (St. Jude Children’s Research Hospital) - July 29th 2021 Robert O. Watson (Texas A&M University) - August 26th 2021 Erika Holzbauer (University of Pennsylvania) - September 30th 2021 Ryan Watts (Denali Therapeutics) - October 28th 2021

doi.org/10.7554/eLife.… eLife - the journal Aligning Science Across Parkinson’s michaeljfox.org So excited to share our latest work on pathogenic LRRK2 blocking cilia in cholinergic striatal neurons and astrocytes!

Thank you Suzanne Pfeffer and Monther Abu-Remaileh labs for stimulating get-together. Stanford collaboration rocks.

Fantastic brunch and research discussion in San Francisco between Aligning Science Across Parkinson’s Team Alessi MRC PPU Suzanne Pfeffer and Team Hurley Hurley Lab & Eunyong Park UC Berkeley MCB. Looking forward to new fruitful collaborations.

So excited to share our new work explaining LRRK2 kinase membrane activation by a cooperative process Aligning Science Across Parkinson’s MRC PPU LRRK2 Central Stanford Biochemistry michaeljfox.org biorxiv.org/cgi/content/sh…

Congrats to my first postdoc Nouf Laqtom on her paper published today; we are reporting the development and first application of the LysoTag mouse to study lysosomes in vivo and at cell-type resolution. Sarafan ChEM-H Stanford Engineering nature.com/articles/s4158…

So excited to share our discovery that phosphorylated Rab GTPases activate LRRK2 by a feedforward pathway! doi.org/10.7554/eLife.… eLife - the journal Aligning Science Across Parkinson’s michaeljfox.org Stanford Biochemistry MRC PPU #Parkinson's disease

So sad to lose my dear friend and colleague... med.stanford.edu/news/all-news/…

Paul Berg did so much for science advocacy! ascb.org/society-news/p… American Society for Cell Biology Stanford Biochemistry

Strife at eLife: inside a journal’s quest to upend science publishing nature.com/articles/d4158…

Amazing to see my colleague Dario Alessi receive this well deserved honour from King Charles for his many scientific discoveries notably the function of the #LRRK2 kinase in #Parkinson and leadership roles including leading the MRC PPU and recently Aligning Science Across Parkinson’s Teams

So excited to share: Localization of PPM1H phosphatase tunes Parkinson’s disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis | PNAS pnas.org/doi/10.1073/pn… Aligning Science Across Parkinson’s michaeljfox.org ScienceofParkinsons Stanford Biochemistry

Rab12 activates LRRK2 kinase in a new way! doi.org/10.7554/eLife.… eLife - the journal Aligning Science Across Parkinson’s Stanford Biochemistry MRC PPU #Parkinsons ScienceofParkinsons

Interesting: New paper from Shahzad S. Khan, Ph.D. Suzanne Pfeffer & @stanford colleagues reports that the cell type specificity of LRRK2-mediated cilia loss is present in human postmortem striatum from patients with LRRK2 pathway mutations & idiopathic #Parkinsons pnas.org/doi/10.1073/pn…