Excited our digital genomic footprinting paper is out today in @nature. We describe ~4.5 million nucleotide resolved TF footprints within 1.6 million distinct regulatory elements across >240 diverse human samples. Thx to ENCODE Project for support. 1/n nature.com/articles/s4158…

Happy to see the papers out from ENCODE 3. A collection of research articles and related content describing the Encyclopedia of DNA Elements, its datasets and tools. nature.com/articles/d4285… Includes beautiful work on mouse development @PengHeCambridge and connects to ファン 🫧

If your lab does TF ChIP-seq and you've struggled with dataset quality and reproducibility, check out our new pre-print on bioRxiv! This short manuscript came out of some troubleshooting experiments we did a while back. Finally wrote it up! 😃 biorxiv.org/content/10.110…

Keller et al. find that the amount of #chromatin sonication is a key variable in the success of ChIP-seq experiments, indicating that monitoring the level of sonication can improve ChIP-seq quality and reproducibility. #G3Journal Dr. Cheryl Keller @cherylkeller.bsky.social bit.ly/3E1203c

This is a great paper!

Love that medley of “Jack Straw”, “China Cat Sunflower”, and “I Know You Rider”.