Jointly with August Huang August Yue Huang we are looking to hire a postdoc in computational genomics. This position is great for candidates who want to gain expertise in analyzing novel single cell sequencing data to study somatic mosaicism in neurologic disease. Spread the word!

New paper online! In 2018, we found a human brain signal that tracks real time fluctuations in mood/anxiety. Now Adam Jackson back-translates this biomarker to mice, dissects its circuit mechanisms, & tests its causal relationship to emotional state. 🧵1/6 authors.elsevier.com/sd/article/S08…

Long non-coding RNAs comprise a large part of the genome, yet loss of one copy (haploinsufficiency) of a lncRNA is not known to cause a human disease. Read our preprint to learn how deletions of the lncRNA CHASERR cause a severe neurodevelopmental disorder.medrxiv.org/content/10.110…

On the International Day of Women and Girls in Science, let’s help girls everywhere pursue careers in science, technology, engineering and math. Our world is better with their ideas and perspectives.

Congratulations to John Rolston , MD, PhD, FAES on his new title-Director of Epilepsy Surgery! We are wishing you continued success in advancing medical excellence and improving lives! 🧠

My lab is recruiting postdocs who are passionate about the genetic and biological mechanisms of epilepsy. Geneticists hoping to learn neuroscience or neuroscientists trying to add genetics to their skillset are welcome to apply. Here is the job ad, plz RT: nature.com/naturecareers/…

Today, NEJM published our clinical study of a novel #CARTCell in patients with #Glioblastoma. Early results with CARv3-TEAM-E suggest safety and bioactivity. Special thanks to all collaborators MGH Neurosurgery and Mass General Cancer Center! nej.md/3VnjUIq

Congratulations Javier Ganz, Sara Bizzotto, Joe Luquette on this transformative paper. Somatic mutations in neurons vs oligos have different rates and patterns, which has important implications for healthy brain development and disease.

So excited to present Blake Madruga 's amazing biorxiv paper on the first of our new generation of open-source 2-photon miniaturized microscopes. The scope has excellent resolution and great sensitivity such that we can image dendrites in RSC and image DG through an intact CA1.

Super excited to share our lab very first review highlighting resident tissue macrophages division of labor and its contribution to tissue/organ function beyond immunity. @jiazhao0 Ilya Andreev. MIT Biology @Ragoninstitute HHMI science.org/doi/10.1126/sc…

My lab in collaboration with Drs Mirzavand @ualberta & Ryait ULethbridge has few open positions in R&D initiatives concerning wireless systems that offer monitoring of behaviour and brain activity in humans and animals. Please retweet! rb.gy/2c3l87

📢 Epilepsy-linked Focal Cortical Dysplasia is due to somatic mutations in mTOR pathway genes🧬. Our study reveals cellular senescence in mutated neurons & senolytic drug efficacy in reducing seizures in mice🧟‍♀️ DOI: 10.1038/s41593-024-01634-2.

So thrilled that our paper on crystallization of working memory representations by practice is now published in Nature! Kudos to Arash Bellafard who with the Vaziri Lab imaged over 73K M2 neurons simultaneously during WM task performance and tracked neurons over days.

Congratulations Frederic Schaper and Michael Fox on this really cool work!

Fascinating work from Gilad Evrony and lab that brings us one step closer to understanding the mechanisms of double-strand DNA changes by surveying single strand DNA damage in health and disease.

Please RT🗣️ I have a fully funded #postdoc position (see flyer) as well as a #ResearchAssistant position! If you are interested in #neurodevelopment, somatic #mosaicism and cell #lineages, please consider applying 🧠🧬 And feel free to contact me if you want to know more!!

Sara is brilliant, collaborative, highly productive, and generous…all the qualities that you need in a great mentor!

Thrilled to share this preprint on our study of somatic mutations in prion disease! Congrats to Gannon McDonough and Alana Cheng, a wonderful collaboration with August Yue Huang, Jiri Safar, ChrisAWalsh and others! Labor of love >7y in the making, finally out! #prion #genetics

Exciting new work by Janet Song , Taehwan Shin and Ryan Doan in ChrisAWalsh lab on functional contribution of non-coding variation to ASD. Many years in the making but well worth the wait!

A really great award for early career physician-scientists with out of the box ideas!