scChIX-seq infers dynamic relationships between histone modifications in single cells go.nature.com/3vvReyT

Oncode Institute De KNAW UMC Utrecht ISTAustria Jake Yeung Alexander van Oudenaarden Co-lead author Jake Yeung goes #behindthepaper on quantifying the relationships between histone modifications and how those relationships change across cell types or during differentiation go.nature.com/3Z5RvWL

Proud of Silke and Robin for developing MAbID, a technology to jointly map all major chromatin states in the same cell Read all about it: doi.org/10.1101/2023.0….

Excited to share the publication of our new paper "Sex-dimorphic and age-dependent organization of 24-hour gene expression rhythms in humans" in Science Magazine by The Naef Lab and Lorenzo Talamanca #circadian #gtex #aging #circadianmedicine science.org/doi/10.1126/sc…

John Hogenesch We've been approaching the problem in terms of a donor internal reference + a tissue-specific shift that is uniform across the population, so we agree that tissues can be shifted, as they turn out to be.

The Journal of Chemical Physics would like to announce the two winners of the 2022 JCP Best Paper by an Emerging Investigator Awards.

Excited to share our latest #research paper: "Mice with humanized livers reveal the role of hepatocyte clocks in rhythmic behavior." Deep dive into our findings here: science.org/doi/10.1126/sc… #CircadianBiology #Chronobiology

Couldn't have asked for a better PhD mentor. Miss our long and frequent conversations about biophysics and gene regulation. Congrats Felix!

Glad to see ExplaiNN published finally. Tweetorial thread from preprint 👇🏽 x.com/manusaraswat10…

Clustering algorithms report clusters even when none exist. In single-cell RNA-Seq pipelines, novel cell types are often identified by clustering algorithms. Expanding on Kimes et al.'s work, we introduce significance analysis for single-cell RNA-Seq data: nature.com/articles/s4159…

Bye, Viennese Schnitzel; hello, California rolls! I've just moved to College of Chemistry. I'm looking forward to new challenges and collaborations. And I thank the tremendous support and lovely colleagues from ISTAustria over the past few years.