Johan Jakobsson
@jakobssonlab
Director at Lund Stem Cell Center, Professor of Neuroscience at Lund Univ, Stem cells, Epigenetics, microRNA, Reprogramming, Transposons, ERVs, LINE-1
ID: 900703513377984512
24-08-2017 12:57:06
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If you are at #eshg24 and would like to know how a transposable element and its epigenetic regulators cause a neurodegenerative disorder come to my talk on Monday at 11:00 in room A2!🧬🧠Johan Jakobsson Lund Stem Cell Center
Are you at #eshg2024 and want to know more about TRIM28, transposable elements and neurodevelopmental disorders? Come to my talk today at 18:45h in the “Novel genes in neurogenetic disorders” session 🧠🧬 Johan Jakobsson
Very proud we could contribute to this study: the epigenetic control of an intronic SVA #transposon is important for the human disease it causes. Thanks to The Collaborative Center for XDP (CCXDP) for funding. Big up to all authors especially Vivien Horvath & Raquel Garza - a fantastic, rewarding collaboration!
Fantastic new study in NatureStructMolBiol from CCXDP grant recipients Vivien Horvath and Johan Jakobsson describing how ZFN91 affects the transcriptional defects induced by an SVA retroelement that is the cause of X-Linked Dystonia-Parkinsonism. #dystonia rdcu.be/dKdzh
🧬#Transposons are movable DNA elements that contribute to genetic variation and can also cause disease. Diving deep into our genome, Johan Jakobsson has revealed that the heterochromatin status of a disease-causing transposon affects the severity of X-linked dystonia parkinsonism.
📰🧬Lund Stem Cell Center researchers reveal how hidden #DNA elements disrupt gene function in X-Linked Dystonia-Parkinsonism (#XDP). Their study in NatureStructMolBiol offers new insights into how this rare genetic condition is triggered in adulthood. Johan Jakobsson Read ⤵️ stemcellcenter.lu.se/article/how-hi…
Meet Raquel Garza a postdoc in the Johan Jakobsson at Lund University. In our latest Q&A, she opens up about her journey in computational #neurobiology, experiences as a #WomanInSTEM, and advice for international researchers. Dive into Raquel's story: 👉stemcellcenter.lu.se/Diverse-Perspe…
X-linked dystonia–parkinsonism is a neurodegen. disorder resulting from an intronic SINE-Alu-VNTR retrotransposon in the TAF1 gene (=dysregulation of TAF1 transcription); Jimi Rosenkrantz 🖖🏻 et al finds that deleting ZNF91 worsens the phenotype of XDP pnas.org/doi/10.1073/pn…
I happily wrote a Preview for the recent HUSH2 story Molecular Cell from the Tchasovnikarova lab Preview: tinyurl.com/5n6jrwut Article: sciencedirect.com/science/articl… The HUSH-HUSH2 link from L1 transcription to innate immunity could complicate efforts to target L1 in disease.
What fuels a lifetime of discovery? Prof. Olle Lindvall, a jubilee doctor at Lund University and pioneer in brain repair, reflects on 50 years of neuroscience. Discover his journey from student to neuroscientist and his advice for future researchers ⤵️ stemcellcenter.lu.se/article/what-f…
Proud to have contributed to this fantastic study led by Christopher Douse . HUSH for the world! nature.com/articles/s4146…
1/23 We are excited to announce that our most recent study “In vivo dendritic cell reprogramming for cancer immunotherapy” was published in Science Magazine. science.org/doi/10.1126/sc… Here is a summary of what we discovered!
📰New research led by Prof. Filipe Pereira and Pereira Lab brings the team one step closer to developing an #immunotherapy to reprogram tumor cells into immune cells, helping the body fight cancer. The findings are now in Science Magazine. Read more ⤵️ stemcellcenter.lu.se/article/resear…
We started the academic year by discussing transposons for two days at the beach! Lots of new data soon coming your way… Lund Stem Cell Center #TEs #transposons
🧑🔬Meet Emanuela Monni, Director of the Lund Stem Cell Center Imaging Facility! In our latest Q&A, she reflects on her 15-year journey in academic research and how #inclusivity & #teamwork have shaped her success as a scientist. Discover her story ⤵️ stemcellcenter.lu.se/Diverse-Perspe…
Delighted that this is finally out! Thanks to Geoff Faulkner Todd Macfarlan and the other reviewer for good and constructive comments that arrived in my inbox the day after my second child was born... paper here nature.com/articles/s4146…. Short reflection on new stuff...