Little is known about epigenetic mechanisms such as RNA 5- methylcytosine (5mC) modification in regulating IgA synthesis. Study revealed TRDMT1-induced RNA 5mC methylation regulates IgA class switch, and inhibition of RNA 5mC by 5-azacytidine may ameliorate progression of IgA

🎙️New ASN Kidney Translation podcast episode explores issues of gender equity in nephrology, including equal access to mentorship & research opportunities, fellowship programs’ parental leave policies, representation in RCTs, and more. bit.ly/KTPOD81424

Frailty poses a significant barrier to successful kidney transplantation and could be potentially modifiable. This article is a call to action to incorporate prehabilitation as a major intervention for frailty to increase access and improve outcomes after kidney transplantation

A study explored whether CSL346, a drug that blocks VEGF-B, could reduce albumin levels in the urine of people with type 2 diabetes and diabetic kidney disease. They found that CSL346 did not reduce albumin levels in urine, and some receiving the higher dose of CSL346 had

Clinical trials require substantial time and effort, and artificial intelligence (AI) has the potential to improve the process. Designing Clinical Trials article provides an overview of applications of AI to clinical trial conduct, including recruitment, informed consent, and

A study highlights the role of impaired glucose metabolism in glycogen storage disease type Ia (GSD1a) that supports cell proliferation and cyst formation, using mice in which glucose-6 phosphatase activity was specifically deleted in the kidneys. In various cystic kidney

Notwithstanding growing data affirming safety of incremental hemodialysis for patients with residual kidney function, it is underutilized. Perspective presents patient, nurse, and physician perspectives on incremental hemodialysis, aiming to expand treatment options

Using population-based health administrative databases, study investigators found that 1/3 of children with posterior urethral valves develop major adverse kidney events (death, kidney failure, or CKD) by early adulthood, compared with 1% of the general childhood population.

Study investigators generated a transgenic mouse model expressing the human IgA1 heavy chain, which has a hinge region with rich O-linked glycosylation. Following inflammatory stimulation, the mouse model showed elevated galactose-deficient IgA1 (Gd-IgA1) levels in the serum.

CMS has recently implemented transformative policy changes to assess and address social determinants of health (SDOH) among patients with kidney disease. A Perspective outlines these changes to the ESRD Medical Evidence Report (2728 form), ESRD Quality Incentive Program, and CMS

“Adaptation in clinical trials facilitates accommodation of the unknown in trial design with methodological rigor, often resulting in improved efficiency.” A Designing Clinical Trials article discusses the benefits and challenges of adaptive designs for clinical trials for kidney

New🎙️: Renal artery stenosis (RAS) compromises the capacity of human stem cells (MSCs) to repair mouse kidneys suffering from RAS, partly by microRNAs that alter their mitochondria. Dr. Lilach Lerman discusses her study that found that inhibition of miR-378h restored

Contact JASN Editor-in-Chief Rajnish Mehrotra and Deputy Editor Manjula Kurella Tamura with your late-breaking clinical trial for expedited consideration and peer review. If accepted, your article will publish online simultaneously with #KidneyWk. Learn more: bit.ly/JASNLBCT

Study identified the role of the IL-33/ST2 pathway in Tregs for resolution of kidney injury. Transcriptome of ST2+ Tregs was enriched for reparative factors, including amphiregulin (AREG). Lack of ST2 or AREG in Tregs worsened kidney injury. Tregs protected kidney organoids from

SGLT2 inhibitors and GLP1-RA slow the worsening of kidney disease and improve cardiovascular outcomes in patients with CKD. A study shows that among patients with CKD, these agents are frequently discontinued, and discontinuation is associated with hospitalization, race,

A Mechanisms of Kidney Diseases article looks at the convergent evidence demonstrating that aquaporin-1 (AQP1) facilitates water transport across endothelial cells in the peritoneal membrane, a key process for peritoneal dialysis, the leading modality of home-based dialysis

Study investigators identified a structural sequence change in the messenger RNA of the gene COL4A4 that could alter the protein function to be associated with hematuria. Using a molecular assay, they also demonstrated that the same structural sequence change produces a

Study compared oral torsemide and furosemide in patients with heart failure to measure any pharmacokinetic or pharmacodynamic differences. Oral torsemide was not superior to furosemide in measures of renal tubular delivery or duration of action. The greater natriuresis from

Study revealed a disrupted regulation of glycolysis in peritubular endothelial cells as an initiator of microvascular rarefaction in CKD. Restoration of peritubular endothelial cell glycolysis in CKD kidney improved microvascular rarefaction and ameliorated fibrotic lesions