Our paper on scrambling the human genome is finally out 🍳 ! What a crazy journey this has been with my fantastic collaborator Jonas Koeppel 🎉 Make sure to check out his awesome 🧵 about our technology to create genetic diversity in human cells! 🧬

Structural variants (SV) impact more nucleotides per human genome than other forms of genetic variation. To better understand SV impact, we developed a method to 'shuffle' mammalian genomes and characterize them with single-cell resolution in a pool. biorxiv.org/content/10.110…

Our latest, livin' the dream, synthetic shuffling of mammalian genomes, conceived+executed by the incredibly creative Sudarshan Pinglay (thread below). Paving path to MPRAs of scrambled genomes 😀 See also amazing parallel work by Jonas Koeppel Leopold Parts Raphael Ferreira george church

See below for details – please RT! postdoc sanger.wd3.myworkdayjobs.com/en-US/Wellcome… ARA sanger.wd3.myworkdayjobs.com/en-US/Wellcome… ARA sanger.wd3.myworkdayjobs.com/en-US/Wellcome…

Our latest out today in nature. We profiled 12 million single cells from mouse embryos spanning gastrulation to birth, defined cell type tree from zygote to birth, and unexpectedly found crazy fast changes within first hour of extrauterine life. OA PDF: rdcu.be/dyDAg

Mark your calendars! SynBio6.0 is coming to University of British Columbia in Vancouver on May 16-17 this year! We have an incredible lineup of keynote speakers Rebecca Shapiro Ron Weiss Leopold Parts Pulin Li. Don't miss out--submit your abstract and register now!👉de-boer-lab.github.io/synbio6-0.gith…

New preprint from our lab is up on bioRxiv - a really awesome synthetic genomics paper that Xinyu Lu from the team has been brewing for the last few years. @Xinyu80256297 biorxiv.org/content/10.110…

Excited to share with you our manuscript describing the endogenous protein La as a mediator of prime editing and the development of our PE7 editor, which can improve prime editing. For more, please check out nature.com/articles/s4158…

Ever considered measuring genetic variant effects with prime editing but hesitated due to low and variable editing? Last month, 3 papers showed that large-scale screens can work 💪. A 🧵 comparing the papers of the Francisco J. Sánchez-Rivera lab, the Britt Adamson lab, and Greg Findlay

Our latest, by the brilliant Xiaoyi Li, out in Cell, leverages a new method for mapping genomic locations of reporters to discover massive chromatin effects on prime editing (PE). We then use "epigenetic conditioning" to enhance PE. Paper: tinyurl.com/5n8d9mh2

Really excited about running this conference in October. Speaker line-up is amazing and venue is ideal for scientific disussions. Join us!

Check out our latest publication on how to achieve precise genome editing with base editors! 🧬🎯 Towards perfect editing with Ramiro Perrotta, Svenja Vinke and george church

New synthetic biology / molecular recording lab opening in the New York city, and we are hiring at all levels (research tech / grad student / postdoc), so please reach out to me via choij10 _at_ mskcc.org!

Excited to share our story on polymerization in ZBTB transcription factors, which was published in the July 11 issue of Molecular Cell! cell.com/molecular-cell… 1/n