Variable performance of AlphaMissense across 18 genes which had previously demonstrated association between rare coding variants and hyperlipidaemia, #hypertension or type 2 #diabetes nature.com/articles/s4143… European Journal of Human Genetics

Now published! Stephen Decker and I discuss potential biophysical mechanisms by which membrane lipids influence OXPHOS. Cell Metabolism cell.com/cell-metabolis…

Very excited to share our work published in Science! In collaboration with Paras Minhas, MD, PhD and the Andreasson Lab at Stanford, we uncovered that modulating glucose metabolism through IDO1 inhibitors can restore cognition across Alzheimer’s pathologies! science.org/doi/10.1126/sc…

Huge congratulations to John Solaro UIC Physiology on receiving the ISHR Distinguished Leader Award! Inspiring award lecture ISHR North American Section 2024. 👍❤️👏 Also congrats to Judith Simcox PhD on the NAS 2024 Agilent technology innovation lecture! Excellent talk! 🎉Proud of you❤️

Congratulations to Lainy Von Bank for completing her thesis and defense in the Simcox Lab! What impressed me most about Lainy was her ability to always push herself and her fearlessness in tackling the hardest experiments. She is everything I hope for the future of science.

Lainy has been an essential mentor to every Simcox Lab member - congratulations on a stellar thesis defense! You are an inspiration!

Congratulations to Ann Palmenberg on receiving the UW–Madison CALS 2024 Honorary Recognition Award! The award is among the highest honors bestowed by CALS. Read more: biochem.wisc.edu/2024/08/26/ann…

Thrilled to share our new paper at CELL Cell ! Our work shows how PS is made and how inhibition of PS synthesis promotes LDL uptake, potentially lowering blood cholesterol levels. authors.elsevier.com/a/1jgTE_278y%7…

The endothelin system is traditionally known for regulating vasoconstriction/dilation. Our new paper in Nature Communications shows EDN3-EDNRB induces the browning of human white adipocytes via cAMP-EPAC1-ERK activation. shorturl.at/Os6ET Chih-Hao Wang, Tadataka Tsuji, Farnaz Shamsi

Please share with colleagues who may be interested!

Mitochondrial translation is the primary determinant of secondary mitochondrial complex I deficiencies: iScience cell.com/iscience/fullt…

Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳 Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!  biorxiv.org/content/10.110…

Sortilin controls adipose tissue fatty acid oxidation by substrate fuel selection during beige fat activation and provides a potential targeted approach for the treatment of metabolic diseases #obesity Nature Communications nature.com/articles/s4146…

Hello #thermogenesis and #adipose folks, Ucp1 lovers and non-canonical lovers: Our recently generated Ucp1 and Ckb conditional mice will soon be available at The Jackson Laboratory: jax.org/strain/039540 jax.org/strain/039539

Thanks Cell for selecting me as one of "50 Scientists that Inspire" for your 50 year anniversary issue. I enjoyed this interview where I spoke about my thoughts on innovation in science, our biggest findings, and my hope for the future of science.

Physical exercise mediates cortical synaptic protein lactylation to improve stress resilience dlvr.it/TCw1tP

Just out today in Nature Neuroscience led by Ebrahim Asadollahi & Klaus-Armin Nave MPI for Multidisciplinary Sciences. Pleased to have contributed. Oligodendrocytes break down & burn their fat when glucose is limited to fuel white matter. #Metabolism flexibility always key to survival. nature.com/articles/s4159…

Excited to share our study in Cell on expanding the druggability of GTPases beyond K-Ras and start putting the entire family (150+ proteins) on the map of drug discovery! Kevan Shokat UC San Francisco UCSF Helen Diller Family Comprehensive Cancer Ctr HHMI (1/7) cell.com/cell/fulltext/…

So happy and excited for been selected as one of the winners for the 2024 ASBMB Molecular Motifs bioart competition! Click the link to see all the beautiful images that will be featured in the 2025 ASBMB calendar 🎉 Rutter Lab asbmb.org/asbmb-today/pe…

Cool new preprint from Amgen 🧪🔬🧬 introducing LYMTACs, bifunctional small molecules that target cytosolic proteins to lysosomes biorxiv.org/content/10.110…