You can't do genetics without the involvement of patients and their families! A special thanks to those who have gotten involved in our NIH-sponsored studies on hydrocephalus, vein of Galen malformation, and others. THANK YOU - and blessings for health and joy in 2020!

A new paper in World Neurosurgery Journal explores the challenges faced by teens w/ #hydrocephalus when transitioning from pediatric to adult health care & highlights the recommendations that came out of HA’s Transition Summit. Read it for free for a short time! bit.ly/39aSRVO

Motile cilia not primarily as CSF propellers but transducers of neural stem cell fate signals? Relevance for kids with hydrocephalus (and other disorders). Nice job ⁦Duy Phan MD, PhD⁩! ⁦Kahle Laboratory⁩ ⁦MGH Neurosurgery⁩ ⁦Broad Institute⁩ sciencedirect.com/science/articl…

Genomic basis for the most common space-occupying brain lesion in humans. Congrats to Adam and other ⁦Kahle Laboratory⁩ team members and ⁦GeneDx⁩ and ⁦Sheng Chih Jin⁩. Thanks to patients and their families! ⁦Mass General Research Institute⁩ ⁦MGH Neurosurgery⁩ nature.com/articles/s4159…

Congratulations to all team members behind this publication in Cell regarding the molecular mechanism of acquired hydrocephalus and resultant treatment considerations. MGH Neurosurgery Mass General Research Institute Boston Children's Broad Institute massgeneral.org/news/press-rel…

Multi-omic analyses reveal de novo variants causing genetic neurodevelopmental conditions in up to 16% of cases of patients with cerebral arachnoid cysts, suggesting that surgery may not improve non-mass effect related symptoms Kahle Laboratory Adam Kundishora, MD nature.com/articles/s4159…

Excellent talk by Dr Kristopher Kahle of MGH Neurosurgery on the utility of multi-omics in clustering and managing neurosurgical diseases like congenital hydrocephalus. Omics may be our generation’s surgical microscope Kahle Laboratory

Congenital Hydrocephalus patients & families, Join our NIH-sponsored study on discovering new genes in Hydrocephalus! Participation is free and easy. To get involved or learn more, visit: kahlelab.com/join-study Kristopher Kahle, MD, PhD [email protected]

Vein of Galen Malformation patients & families, Join our NIH-sponsored study on discovering new genes in VOGM! Participation is free and easy. To get involved or learn more, visit: kahlelab.com/join-study Kristopher Kahle, MD, PhD [email protected]

Moyamoya Disease patients & families, Join our NIH-sponsored study on discovering new genes in MMD! Participation does not require travel- it's free and easy. To get involved or learn more, visit: kahlelab.com/join-study Kristopher Kahle, MD, PhD [email protected]

Overwhelmed with gratitude for the four young men from Kahle Laboratory who matched today in neurosurgery - Tyrone DeSpenza (Duke Neurosurgery ), Ben Reeves (BarrowNeurological ), Emre Kızıltuğ (Michigan Neurosurgery), and @kedousmekbib (Mayo Clinic Neuro). I couldn’t be more proud+thankful for these soldiers!

Congrats to ⁦Kahle Laboratory⁩ class of 2024 - Ben Reeves, Tyrone DeSpenza, ⁦@kedousmekbib⁩, and ⁦Emre Kızıltuğ⁩ - moving on to bigger and better things: neurosurgery residency! Thank you gentlemen! ⁦Yale School of Medicine⁩ ⁦Yale Department of Neurosurgery⁩ ⁦MGH Neurosurgery⁩