The point of this montage was not to suggest facial features can be used as a "clock". My point was we are sensitive to age as a "feature" of someone. I gave only 6 ages as options; that constrains the response. Looking only at one panel, estimates could reasonably vary by ±20%

1/n Thoughts on Neurofilament Light (NfL) as a neurodegeneration biomarker. I expect to hear a lot on it in the upcoming #Tofersen Adcom. U.S. FDA refers to it as a promising biomarker of neurodegeneration in several diseases at the Relyvrio #ALS approval👇Robert Howard Ash Paul

Make mine a Talisker

Ooops

Lecanemab is neither safe nor effective for Alzheimer's patients: Against the FDA approval - Sign the Petition! chng.it/bKSSzkD2 via Change.org In my opinion we are going down a dangerous road. We need to consult our maps and re-orient ourselves. Please consider signing.

Lon S. Schneider, MD Karl Herrup Tbf, this is getting way more exciting than science! I'll be there for the drama 🍿🍿🍿

Is there an FDA-approved drug to maintain mental function in Alzheimer's? I see this tweet from FDA (pic) and did a double take to ask this question. Where I'm coming from I know the recent beta-amyloid drugs are still pending clinical outcomes. I thought at most you could say

Only a few hours left to see one of the best posters at #AAIC. Oligodendrocytes rule!!4

Poster is online. Feel free to download.

Thank you

Help me out here. If AD is defined by amyloid then you can’t have *any* stage of the disease without amyloid. Mutations in Mapt show that you can have tau-driven dementia. But these dementias are not AD by definition. So isn’t this a bit of circular logic?

We agree. I made the tau comment mostly because I worry about the fuzzy way we define AD (made even worse by Jacks presentation at #AAIC23 ). We are quick to ascribe causality to correlation and need to be more careful.

Well, here we go. Fasten your seatbelts. This is going to be a rough ride.

Some of us might take issue with characterizing it as “pretty solid”. I actually wrote an entire book unpacking the evidence and while there were a few sticks left standing here and there, the evidence in support of the current biomarkers came away looking flimsy at best.