If you’re interested in testing EarlyBac for your protein expression, you could get vectors from Addgene  addgene.org/Hiro_Furukawa/. The updated protocol is on our lab website  furukawalab.labsites.cshl.edu/protocols/earl… Please let us know if you need any help.

The NIH Director’s Blog details the work of Furukawa Lab CSHL that involves 3D modeling of one of the largest pores in human neurons… the results may surprise you. 🐙

Our paper is finally out in Cell! cell.com/cell/fulltext/… During the revision, we solved one more structure (H225F or KALI), performed more electrophysiological, computational, spectroscopic, and biochemical experiments, and conducted optogenetics experiments using KALI. (1/n)

We are very proud! In this work we discovered a pentameric TRPV3 channel! Scheuring Lab Crina Nimigean Yuan Lab Shifra Lansky Jingying Zhang @labnavid Yining Jiang Weill Cornell Medicine Anesthesiology WCM Office of the Research Dean Molecular Biophysics Training Program

Explore the forefront of scientific innovation with us at Cold Spring Harbor Laboratory!! - Postdoctoral Fellow Position - Furukawa Lab schooljobs.com/careers/cshl/j… via @GovernmentJobs

We are pleased to share our latest publication, which unveils the inaugural structures of the GluN1-3A NMDA receptor, an excitatory glycine-gated ion channel. Conformational patterns are unique and robust. By Kevin Michalski #cryoEM #electrophysiology science.org/doi/10.1126/sc…

Postdoctoral Fellow - Cold Spring Harbor Laboratory Furukawa Lab CSHL Seeking a postdoc to explore neurotransmission and autoimmunity using cryo-EM, electrophysiology, etc. Join our team! jobrxiv.org/job/cold-sprin… #autoimmune_diseases #cryo_EM #cryo_ET #io... jobrxiv.org/job/cold-sprin…

nature.com/articles/s4158… Great work by Elizabeth Kim (Elizabeth Kim) and Xiaoan Wu! Collaboration with teams of Peter Larsson (Linkoping University), Alessio Accardi (accardilab) and Peter Goldstein Weill Cornell Medicine Weill Cornell Medicine Anesthesiology. Free link: rdcu.be/dPAy1

Structural switch in acetylcholine receptors in developing muscle disq.us/t/4pyrh6a

We are pleased to report the unique dual-ligand-gating mechanism in NMDAR. Ed Twomey described our work perfectly. #Traynelis_lab #Liotta_lab Tsung-Han Chou Max E Elijah Zorro Ullman nature.com/articles/s4158

nature.com/articles/s4159… We are excited to share our latest research on the structural and functional mechanisms underlying anti-NMDAR encephalitis. Our study reveals that three antibodies, isolated from different patients, bind to distinct regions of the NMDARs 1/n)

One of the IgGs cross-links two NMDARs at a 2:2 stoichiometry, while the other two do not and primarily bind at a 1:1 stoichiometry, with two GluN1 subunits binding to the two Fab arms. The binding patterns influences the de-clustering of synaptic NMDARs at the synapse. 2/n)

Notably, all three antibodies are associated with a reduction in sEPSCs. A fruitful collaboration with the Geis lab at Jena. We are also pleased to see a related paper from the Zhu lab on this topic in the same issue. Kevin Michalski Taha Abdulla Sam Kleeman 3/n)