Sometimes it looks like Exhausted CD8 T cells recover from exhaustion - cell surface phenotype, even RNA and scRNA..But underlying epigenetics of exhaustion can be retained, impacting future responses. Epigenetics Scarring - new work by MoSalah A-Hakeem * (محمد صلاح (بتاع المناعة nature.com/articles/s4159…

Happy to share the reappointment of Dr. Speck to the Chair of the Department of Cell and Developmental Biology at UPenn for a second 6 year term med.upenn.edu/evpdeancommuni…

Congratulations to Dr. Nancy Speck (Speck Lab) on her reappointment as Chair of CDB! 🎉 We look forward to continuing our department's growth under you leadership.

Good description of why waning Ab levels are not the whole story. Memory B cells. More great work from Penn, where mRNA vaccines began, and ⁦E. John Wherry⁩. ⁦Penn Medicine⁩ (A top 10 Bloomberg story today) bloomberg.com/news/articles/…

Our work on single-cell ribosome profiling is out! Huge congrats to Michael VanInsberghe who was brave enough to embark on this pretty crazy experiment that turned out to work beautifully. Thank you Jeroen van den Berg, Amanda Andersson-Rolf and Hans Clevers. Check it out: nature.com/articles/s4158…

My paper is officially officially accepted AND I accepted a major job offer. It has been a BIG week and it’s only Tuesday

#RUNX1Week is only 1 week away! Register today to join discussions on "Modeling Clonal Hematopoiesis & Uncovering Drivers of Clonal Evolution" with experts from @sloan_kettering, NIH NHLBI, National Human Genome Research Institute, St. Jude, UVA School of Medicine & Albert Einstein College of Medicine - Official. Click here: runx1-fpd.org/conference

"When I was a postdoc we poured our own gels, cut our own markers, and distilled our own phenol. It took me 6 months to sequence 1.5 kb of DNA. Times have changed!" Dr. Nancy Speck Speck Lab #NPAW2021 #BPPpostdocs @UpennBPC CHOP Postdoc Alliance

Only one hour until our 5th Annual Conference - #RUNX1Week: Creating Connections begins! Join the first scientific discussion at 10am ET on Modeling & Targeting #ClonalHematopoiesis with Dr David Steensma, MD Speck Lab Dr Lucio Castilla & Dr Serine Avagyan ow.ly/TLat50Gh34C

There will be six talks from current students: Maxwell Chappell, Elizabeth Howell Elizabeth Howell , Aileen Ren Aileen and.... 4/7

Stop by #RUNX1Week at 2:40 pm ET for a #RUNX1 101 with NIH's Natalie Deuitch & UW Health | Carbone Cancer Center's Kelcy Smith-Simmer. Then at 3:25 pm ET, Dr Nancy Speck of Speck Lab & Dr Katrin Ericson share key takeaways from the Scientific Sessions held earlier this week! ow.ly/8qB450GkDSL

Final lab meeting presentation today 😊😬👩🏼‍💻

Have you ever wondered what makes an endothelial cell permissive to be reprogrammed by RUNX1 to a blood cell? Well I have the answer for you - see article and 🧵genesdev.cshlp.org/content/early/…

We're excited to have CAMB Students Yeqiao Zhou Yeqiao Zhou 周叶峤 (Faryabi R. Babak Faryabi and Pear labs) and Elizabeth Howell Elizabeth Howell (Speck Speck Lab lab) give their talks during the CAMB Symposium a little later today at 3:15pm and 3:40pm! med.upenn.edu/camb/camb-symp…

Behind the scenes Speck Lab photo shoot! First new lab photo in several years #NewProfiePic

DM us if you're interested in watching and we'll share the link 🤓

Very exciting times to be doing cellular barcoding work!! Glad to see some of our research featured in the The New York Times. Great to be collaborating with Dr. Len Zon Jay Shendure and Vijay Sankaran nytimes.com/2021/11/29/hea…

Our graduate student Elizabeth successfully defended her thesis yesterday! Thank you to everyone who came both in person and virtually !

1 year later, people who participated in Moderna trials at Penn Medicine share what motivated them to volunteer ft. Suean Fontenard (Speck Lab/ UPenn CDB), Adrian Reynolds (Penn FRES), Mickey Breadenwater (he/him/él) (Palliative Care) & Mary Kerstetter (Fountain Woods) bit.ly/3Fh6gvz