Excited to share our preprint: 'In-tissue molecular architecture of β-amyloid pathology' by cryoET. Thank you Conny Leistner, Ailidh Burgess, @ABSL and a fruitful collaboration with Martin Wilkinson RadfordLab Neil Ranson. #cryoEM #TeamTomo #alzheimersdisease biorxiv.org/content/10.110…

Feeling festive 🎄🎄🎁🎁 with Yehuda Halfon 🏳️‍🌈 as the best Father Christmas dishing out secret santa presents, obligatory crackers and pizza! And some excellent party games .... More to follow... Amazing organisation from our social secs Alex Flynn Iso Jackson Hirst 💛💛

Our paper is out: In-tissue cryoET of amyloid plaques (in AppNL-G-F mouse model). rdcu.be/dcmnr. Fibrils, protofilaments, branched fibrils and non-amyloid constituents. Well done Conny Leistner! And Martin Wilkinson for exquisite Arctic fibril cryoEM structure. #teamtomo

In situ amyloid in Alzheimer's brain! These tomos still blow my mind 🤯. Grateful to work with the best team Joshua Jenkins Nayab Tom Yehuda Halfon 🏳️‍🌈 René Frank RadfordLab Jeroen Hoozemans #teamtomo and to all those who donate their brains to science ❤️ biorxiv.org/content/10.110…

Our preprint is out! in situ cryoET of amyloids in post-mortem Alzheimer's disease brain. Its been a pleasure to work on this project with a great team Maddie Gilbert, Nayab, Tom, Yehuda Halfon 🏳️‍🌈, Jeroen Hoozemans, RadfordLab, René Frank. biorxiv.org/content/10.110…

Job advert: We have a cool structural virology postdoc position in the FontanaLab and Barr Lab investigating the cellular trafficking of Influenza A virus vRNPs utilising techniques in #cryoET #CEMOVIS and #cryoFIB! See link for details/contact info jobs.leeds.ac.uk/vacancy.aspx?r…

Interested in 𝑖𝑛 𝑠𝑖𝑡𝑢 structural biology? We're thrilled to announce the Cheney PhD scholarship programme - a multi-year scheme offering up to 5 𝐡𝐨𝐦𝐞/𝐔𝐊 PhD scholarships a year, for the next five years! findaphd.com/phds/program/f… astbury.leeds.ac.uk/CheneyPhD/

Our team at #CZImagingInstitute is excited to share the #CryoET Data Portal beta release. With over 13,000 tomograms, it’s the start of what we hope will be a large, open-access portal of high-quality, standardized & annotated cryo-ET data. bit.ly/3T9sZ6D

Just in time for Christmas! Excited to see our fibril structures published, showing changing polymorphism of IAPP during the course of amyloid assembly. As always, brilliant team effort from the amyloid team, thanks all The Astbury Centre Neil Ranson RadfordLab sciencedirect.com/science/articl…

3 months to go until the Astbury Conversation 2024! This event promises to bring people from across the globe together to discover, explore and inspire ideas whilst showcasing the latest innovations in molecular biology. Register your place today eu.eventscloud.com/website/11502/…

Had a great time and asked a lot of questions in the iNEXT-Discovery cryo-FIB and tomography workshop during the week at CEITEC🔬Thanks to all instructors and the insightful lectures! Can't wait to go back and mill my samples🤓

Thrilled to see our in-tissue cryoET work on amyloids out in Nature! It’s been a really fun collaboration with all involved. Maddie Gilbert, Nayab Fatima, Tom O’Sullivan, René Frank, AstburyBiostructure. #TeamTomo. nature.com/articles/s4158…

1/2: Our paper is out nature! #teamtomo of β-amyloid and tau within post-mortem Alzheimer’s disease brain. Lots to see incl. resolving the backbone polypeptide trace of a cluster of 136 tau filaments from a single in-tissue tomogram.rdcu.be/dNlNo

Such cool and challenging science 🥳 hugely well deserved ✨

📢 The Wellcome/MRC Cryo-ET Sample Preparation Workshop 2024 is coming up! 📅 Date: 14-18 October 2024 📍 Location: eBIC Beamline ⏰ Registration deadline: August 31st 🔗 More information and how to apply: diamond.ac.uk/Instruments/Bi… Wellcome Medical Research Council #CryoET #CryoEM

Particularly excited to share our latest work, where we visualize how myosin motor forces alter the structure of actin. We discovered a spiral form of the filament which can be recognized by force-sensitive actin binding proteins. biorxiv.org/content/10.110…