This week's selection of articles and #preprints on #proteostasis thanks to Bims: Biomed News -- biomed.news/bims-proteo/20… Highlight: Hsp47 promotes biogenesis of multi-subunit neuroreceptors in the endoplasmic reticulum elifesciences.org/articles/84798

Lovely of Cambridge University to lay on a garden party for staff at the Botanical Gardens Some of Marciniak Lab there Jenny dickens Joe Chambers

A new article by one of our keen medical students supported by dedicated consultant colleagues ⁦Lance Burn⁩ Teo Wetscherek⁩ ⁦Paul Pharoah (R soul) 🇪🇺🇵🇬🇿🇦🇬🇧⁩ “CT features associated with contralateral recurrence of spontaneous pneumothorax” academic.oup.com/qjmed/advance-…

It is always satisfying to help mentor a keen student and see the final results published!

#ER_literature Endoplasmic reticulum exit sites are segregated for secretion based on cargo size: Developmental Cell cell.com/developmental-…

Wow! "Alveolar fibroblast lineage orchestrates lung inflammation and fibrosis" is a masterpiece! Kudos Drs Tsukui, Wolters & Sheppard for this beautiful work!! Read the paper at nature.com/articles/s4158… and super 🧵below from Tatsuya Tsukui

poke Cédric Chaveroux The ribotoxic stress response drives UV-mediated cell death: Cell cell.com/cell/fulltext/…

Our latest Special Issue "Proteostasis and Protein Quality Control" edited by JMB editorial board member Johannes Buchner BuchnerLab TU München is now published! Read this exciting collection of reviews and research articles here: bit.ly/3xR1lTV

Best figure legend ever written? “D) … after dehydration loops remain (top center), even after a year at room temperature (top right), and even if (bottom right) the sample is subsequently blasted with a shotgun, run over by a car, or hit with a fastball” Cell

#proteostasis An HSF1–JMJD6–HSP feedback circuit promotes cell adaptation to proteotoxic stress | PNAS pnas.org/doi/10.1073/pn…

Long-term live-cell super-res microscopy! 👉🏻our new preprint (tinyurl.com/bdjjju45) reports >6h STED imaging of ER dynamics in live cells with seconds time resolution. It combines low-light imaging and NN-assisted denoising🔬

Interventional radiologist vs Resp ST7

#ER_literature Sestrin2 drives ER-phagy in response to protein misfolding: Developmental Cell cell.com/developmental-…

Such fun day! Started with a lecture about admissions and the Cambridge University medical course from me; a talk about being a medical student by one of our current students, Ranya Kumar who also sportingly agreed to have a medical school mock interview in front of everyone; 1/3

#papworthauthors new publication: CT features associated with contralateral recurrence of spontaneous pneumothorax. buff.ly/4f2Miam #computerisedtomography #CT #pneumothorax Stefan Marciniak @royalpapworth @royalpapres

We’ve worked out how the molecular machines that create acidic compartments can recruit autophagy (self-eating) machinery when they can’t maintain a pH gradient. We are really pleased with this discovery, out in Molecular Cell cell.com/molecular-cell…. 1/16

Estimated number of lives directly saved by COVID-19 vaccination programmes in the WHO European Region from December, 2020, to March, 2023: a retrospective surveillance study 1·6 million lives saved thelancet.com/journals/lanre…

Congratulations & welcome to all the new FY1s who’ve joined the NHS family this week Thank you to all the other colleagues who care for the population #OneTeam #OneNHS

PERK-ATAD3A interaction provides a subcellular safe haven for protein synthesis during ER stress science.org/doi/10.1126/sc…

Moving notice bsky.app/profile/profma…