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The latest about the management of Cerebral Amyloid Angiopathy Amyloid Angiopathy - Review article that includes practical recommendations to prevent Prevent Brain Bleeds in #CAA & therapeutic advances Mariel Kozberg International Journal of Stroke World Health Organization (WHO) World Stroke Org WorldStrokeAcademy journals.sagepub.com/doi/abs/10.117…

Neurovascular dynamics of repeated cortical spreading depolarizations after acute brain injury dlvr.it/S95C80

Illustrative Teaching Case: Bow Hunter's Syndrome #stroke #AHAJournals ahajournals.org/doi/10.1161/ST… Adam A. Dmytriw Robert Regenhardt, MD, PhD

Check out this new paper from our lab, led by the fabulous Valentina Perosa. She investigated the neuropathological correlates of MRI-visible perivascular spaces in patients with CAA and found a direct relationship between dilation and amyloid buildup. link.springer.com/article/10.100…

interested in developing treatment for ICH? come to the Recent Innovations in ICH session at #ISC22 to get some treatment target ideas from the experts.AHA Science Mariel Kozberg Rm220-222 5pm

New paper out! We found hemorrhagic lesions on ex vivo MRI in brain tissue of AD patients who received anti-amyloid immunotherapy. These lesions were associated with severe leptomeningeal CAA, suggesting a possible role for CAA in the formation of ARIA-H. academic.oup.com/braincomms/art…

Meet 2022 MGH Rappaport Research Fellow Mariel Kozberg MD, PhD and learn about her research around hemorrhagic stroke.ow.ly/Oiow50Krj6h MGH Neurology MassGeneral News

Kozberg et al. report blood-brain barrier leakage at the early stages of vascular pathology, a potential trigger for perivascular inflammation and vascular remodelling leading to haemorrhage. Mariel Kozberg Dr. Susanne van Veluw MGH Neurology bit.ly/3ULNsMP

#TopicalReview: "Role of Inflammatory Processes in Hemorrhagic #Stroke" by Drs. Ohashi, DeLong, Kozberg, David Mazur-Hart, Dr. Susanne van Veluw, Alkayed & LaurenHSansing #AHAJournals ahajrnls.org/3GM33rm

New paper! Our wonderful postdoc Leon Munting (who's not on Twitter) analyzed in vivo two-photon microscopy data in unanesthetized mice and found that spontaneous vasomotion propagates along pial arterioles in the same way as evoked reactivity (1/2). See: journals.sagepub.com/doi/10.1177/02…

For all interested: Our proposed pathophysiologic framework for understanding CAA (and maybe other small vessel diseases?) authors.elsevier.com/a/1h7p9_XXc8Ve…

Check out this new review paper by Dr. Emma Koemans and colleagues in The Lancet Neurology. We propose a new pathophysiological framework of CAA disease progression. iCAA authors.elsevier.com/c/1h7p9_XXc8Ve…. (1/4)

#ischemicstroke prevention after ICH requires shared decision making & careful risk benefit assessment! Mariel Kozberg & I review the current literature. UConn Neurology Residency MGH Neurology Erica A Schuyler, MD, FAAN, FANA Ajay Tunguturi Karan Tarasaria Matt Jaffa Rashid Ahmed link.springer.com/article/10.100…

Great talk by Mariel Kozberg on the origin of Cerebral microbleeds, siderosis and possibly also #ICH in patients with Amyloid Angiopathy! Inflammation might be key factor… iCAA ECR network CAA Cerebral Amyloid Angiopathy Dr. Susanne van Veluw

How will anti-amyloid immunotherapies and ARIA affect stroke care? Phil Bilodeau, MD, John Dickson, and I review the latest data on ARIA in the context of acute stroke care and secondary stroke prevention here: secure-web.cisco.com/1xmfXF0oNepoSs…

📢📢 Our dynamic team is looking for a fellow who will engage in stroke-related clinical trials and lead research projects on the interaction between CSVD and AD-pathology 🧠. If you are passionate 🤩, an MD, and interested, contact me!

How does vascular dysfunction progress in #CAA? See our pre-print which used a combo of in-vivo two-photon microscopy and MRI to track changes in #vasomotion, #pulsatility, #CBF, #CVR, and more! biorxiv.org/content/10.110…

The Kozberg Lab is officially online! Kozberglab.com

Kozberg Lab at MGH Neuroscience Day! Very proud of our team!