Very excited to share our Focus issue on Advanced AI in Biology!!!!! Lots of great content here to explore across disciplines, but definitely a plenty for those of you into spatial omics and bioimaging to enjoy!!

Paper read today #605: Nanoscale volumetric fluorescence imaging via photochemical sectioning biorxiv.org/content/10.110… A very inspiring method to section hydrogel-embedded samples for super-thick 3D optical imaging at the nanoscale.

Tweetorial coming soon, but you gotta read this one. #zebrafish thick MERFISH transcriptomics!

We've been asked (thanks Stan Schwartz!) for a summary of this discussion, which I think would benefit people who couldn't attend! I didn't take notes, but I will share from my memory and warmly invite other panelists and #SMLMS2024 attendees to add to the thread!

Mind blowing 🤩👏Achieving optical transparency in live animals with absorbing molecules | Science science.org/doi/10.1126/sc…

A paper in Nature Machine Intelligence discusses a deep learning method that recognizes specific nuclear signatures, which can identify cellular heterogeneity and differentiate between various cell states using a small amount of super-resolution microscopy data. go.nature.com/3MyyqaR

Out today from the Lakadamyali lab! Enhanced Classification of Localized Point clouds by Shape Extraction (ECLiPSE) is a robust feature extraction and classification pipeline for diverse and heterogeneous structures in both 2D and 3D single-molecule localization microscopy data.

Out at Nature Methods just now! nature.com/articles/s4159… We present #SN2N, a flagship level unsupervised denoising solution. It’s fully competitive with supervised learning without needing large training-set and clean ground-truth, using 1 noisy frame for training. (1/n)

Let me introduce: InstanSeg 🦠🔬💻👩‍🔬 This *would* have been a short thread about Thibaut Goldsborough’s PhD work… but he solved too many problems. Now it's a long thread about 2 preprints, a whole new approach to cell segmentation & #opensource software to make it easy to use

Wow, in vivo clearing is taking off: Isotonic and minimally invasive optical clearing media for live cell imaging ex vivo and in vivo biorxiv.org/content/10.110…

We developed a new super-stable RFP for advanced microscopy, like CLEM, Rapid tissue clearing, Live 3D-SIM and live STED. Read this #preprint on Research Square: mYongHong: a structure-guided design of stable and monomeric red fluorescent protein researchsquare.com/article/rs-471…

My lab is hiring a postdoc, don't hesitate to apply! Lots of opportunities to work on Hi-C/Micro-C and super-resolution imaging in Drosophila and mESCs.

We have an open postdoc position in the NeuroCyto lab! Come explore new mechanisms of microtubule turnover and their physiological roles in collaboration with THERY Manuel, funded by ANR for up to 3 years. More info & contact: neurocytolab.org/postdoc/ Thanks for RTs🙏🏻