Out today Cell: Balamurugan Sundaram and Nagakannan Pandian with Thirumala-Devi Kanneganti and team St. Jude Research identified NLRC5 as an innate #immune sensor of NAD+ depletion that drives inflammatory cell death, PANoptosis. authors.elsevier.com/sd/article/S00… Thread👇

New research by Thirumala-Devi Kanneganti in Cell reveals NLRC5 acts as an innate immune sensor and cell death regulator. This understanding has therapeutic implications for treating cancers, infectious diseases and inflammatory disorders. Read more ow.ly/kEPw50Sj8Tn

Oxylipins and metabolites from pyroptotic cells act as promoters of tissue repair nature.com/articles/s4158…

Die to #LiveForever! Kodi Ravichandran Mehrotra Parul &co show nature that cells that die by #pyroptosis do more than secreting inflammatory IL-1, they also allow a caspase-1, COX2, gasderminD dependent production & secretion of PGE2 that potentiates tissue #repair! nature.com/articles/s4158…

Thrilled to share our work with Mehrotra Parul and Ravichandran Labs Kodi Ravichandran identifying oxylipins and metabolites from pyroptotic cells as promoters of tissue repair. Out today in nature Huge thanks to all coauthors and collaborators!nature.com/articles/s4158…

Nature research paper: Oxylipins and metabolites from pyroptotic cells act as promoters of tissue repair go.nature.com/3L0HCnB

Fantastic work from Mehrotra Parul in Kodi Ravichandran lab. I was fortunate enough to watch this project come together from start to finish and Parul's scientific rigour and creativity was a joy to experience. nature.com/articles/s4158…

Cryo-EM structure and description of how #Bedaquiline binds to ATP-Synthase of both host and #mtb!! Incredibly similar binding sites. nature.com/articles/s4158….

Such an important piece of information for those interested in metabolomics!! Van Andel Institute (VAI) nature.com/articles/s4146….

From a brilliant lab! Fendt Lab What a great read. cell.com/cell/fulltext/…

Check this out! Our last translational ferroptosis paper from excellent PhD student. Ferroptosis is a targetable detrimental factor in metabolic dysfunction-associated steatotic liver disease | Cell Death & Differentiation #ferroptosis #MASLD nature.com/articles/s4141…

Such a nice opinion piece by Thirumala-Devi Kanneganti Kanneganti Lab covering our publication on Pyroptotic secretome! nature.com/articles/s4142…

How does #macrophagee #metabolism respond so incredibly fast to TLR triggers? Veit Hornung lab have the forst answers- its not just transcription. Phosphorylation of PFKL begins go steer the metabolic switch!

#ImmunoCannibalism! #EveryCellIsAnImmuneCell! The Fuchs lab &co show nature that stem cells sense lipids released by apoptotic cells (& retinoic acid from healthy cells!) & become phagocytic to clear cell corpses & maintain tissue homeostasis! nature.com/articles/s4158…

This paper from Tim Lämmermann Lab is Bomb!! Entire neutrophils getting trapped by Mast cells to enhance functionality! Reads like beautiful science and feels like an alien abduction movie! MPI of Immunobiology & Epigenetics sciencedirect.com/science/articl…

Nature research paper: Lysosomes drive the piecemeal removal of mitochondrial inner membrane go.nature.com/4fWhHvq

A number of new studies on gasdermin were published recently. Broz Lab and I put together a review to summarise and discuss our current understanding of gasdermins during cell death and inflammation. nature.com/articles/s4155…

📢Call for Applications! BRIC-NII is hosting an "Advanced #Immunology Course" in October for PhD scholars, postdocs, & clinical researchers. It is your chance to learn from experts in the field📚🔬🦠 Apply now! Application Deadline⌛️ 22 Sept 🔗bit.ly/nii_AIC