In honor of the mesoSPIM: Clear Images. Big samples. Open source. benchtop publication, I’m happy to announce that the NIML MesoSPIM build has been completed by the talented Sharon King. Looking forward to many exciting imaging experiments!

Our TESOS (Transparent Embedding Solvent System) method paper is finally online. nature.com/cr/volumes/34/… A fundamental challenge for all tissue clearing methods is the inevitable loss of resolution and signal quality in the deep tissue regions. TESOS was specifically designed to

First, we tackle direct 3D segmentation: not 2D plus stitching. We show transformers (SwinUNetR) can outperform CNNs in a new challenging mesoSPIM: Clear Images. Big samples. Open source. acquired dataset!

@mesoSPIM is proud to be a core platform of Adaptive Brain Circuits in Development and Learning Program of University of Zurich. Summary of the Program's research goals and activities (in German): adabd.uzh.ch/de/adabdmadeea… illustrations by Marco Garbelli, PhD 🔥

🎉We're thrilled to announce the #MICCAI2024 SELMA challenge on self-supervised learning for 3D light-sheet microscopy image segmentation. Explore our dataset, which contains 3D light-sheet microscopy images of various labeled structures and is possibly the largest 3D microscopy

A @mesoSPIM #lightsheet #Microscope is on the cover of the The Royal Society Royal Society Publishing Phil Transactions A July 2024 issue on #open #Microscopy by Dr Caroline Müllenbroich Richard Bowman Benedict Diederich Gail McConnell & Co! royalsocietypublishing.org/toc/rsta/2024/…

After many days of coding and testing on various microscopes, our latest release of mesoSPIM_control v1.9.0 software is out: github.com/mesoSPIM/mesoS…

Did you know?

We upgraded our SQUID microscope PrakashLab Cephla with a compact automatic filter wheel from ZWO, inspired by the new #OpenHardware Benchtop mesoSPIM: Clear Images. Big samples. Open source. microscope documentation. Works great. Wenzel Lab

We are looking for a multiphoton microscopy enthusiast to join our team. If you love tinkering with lasers and lenses and like Open Source DIY microscopes, please take a look at what we have to offer: inss.org.uk/careers

Here's a glimpse into our clearing station UZH Microscopy. Zebrafish clearing by and for @mesospim @UZH_AdaBD team! Interested in clearing and/or large sample imaging at our @mesopim? Reach out for more details! zmb.uzh.ch/en/Available-S… 🔬#Zebrafish #imaging #fluorescencefriday

We are looking forward to participate in this workshop next week! On Aug 8 (Thursday), at 10 AM CET Nikita Vladimirov ☮️🌍 will talk about Benchtop @mesoSPIM and give a remote demo of the system located at UZH Microscopy, assisted by Marco Garbelli, PhD. Online participants can join for free!

I am thrilled to announce that I've been awarded a Branco Weiss Fellowship to push the frontiers of imaging neuronal activity during social interactions Florian Engert MCB_Harvard and to support starting my own lab! 🥳🐟🔬🔭 #Microscopy brancoweissfellowship.org/fellow/voigt/

It is #SPIM day, yes 20 years ago this Science issue came out... And with great friends and support 20 years later LSFM is everywhere... Pavel Tomancak Francesco Pampaloni Gary Laevsky @[email protected] science.org/doi/10.1126/sc…

Go, Benchtop mesoSPIM!!!

Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samples | Nature Biomedical Engineering nature.com/articles/s4155…

We've carefully counted publications that used a mesoSPIM microscope, and found 78 of them, ~2x more than previously assumed 😱 🎇Including 7 PhD dissertations 👩‍🎓 Is your publication listed? If not, let us know! Full list available for download: mesospim.org/publications/

Assembling of the mesoSPIM: Clear Images. Big samples. Open source. in progress with colleagues of ENS Paris-Saclay. A great interdisciplinary project with the prospect of an original instrument in Ile de France for 3d imaging of large cleared samples. Université Paris-Saclay Infrastructure EMERG'IN IERP_aqua GIS IBiSA INRAE Santé Animale

This basically starts a New Age in microscopy of large living organisms, mammals included. OMG, what a time we are living in. Hard to over-estimate the importance of this tissue clearing method.