This is cool! Uses NMR to identify conformations important for STING signaling that aren’t visible in crystal structures. Important for therapeutic targeting of STING #proudformerPI

Janus kinase (JAK) inhibitors improve antitumor responses Science Magazine Melina Marmarelis Andy Minn E. John Wherry Veronika Bachanova MD Teijaro Lab science.org/doi/10.1126/sc… science.org/doi/10.1126/sc… science.org/doi/10.1126/sc…

The BIG 3 innate immune pathways: TLRs, RLRs and STING. These all use a pLxIS motif to control anti-viral interferon responses. Dozens of orphan pLxIS proteins are present in humans and mice. I wonder if pLxIS orphans represent new innate immune pathways.

I am incredibly excited to share our work on the diverse mechanisms and functional responses of type I interferon adaptors via pLxIS motifs! authors.elsevier.com/c/1jJz73vVUPRm…

REVIEW Nature Immunology The balance of STING signaling orchestrates immunity in cancer nature.org/articles/s4159…

Casali and colleagues describe a mouse model with a human lymphoid and myeloid immune system, that expresses BCR and TCR repertories as diverse as humans and mounts antibody responses to infection and vaccination. Read it here: rdcu.be/dLY2o nature.com/articles/s4159…

Our latest work on developing a potent and specific tool for activating or repressing endogenous splicing events is out! authors.elsevier.com/c/1jJci3vVUPRm…

Latest from us. How a rare genetic disorder inspired a broad spectrum antiviral drug. Started by Justin Taft continued by Roosheel Patel and Dr. Akalu in our lab. Columbia Children's Health Lipschultz Precision Immunology Institute Icahn School of Medicine at Mount Sinai Columbia University nam02.safelinks.protection.outlook.com/?url=https%3A%…

VEXAS‐Defining UBA1 Somatic Variants in 245,368 Diverse Individuals in the NIH All Of Us Cohort - 2024 “Variant allele fractions were lower than reported in clinical VEXAS cohorts, and bioinformatic analysis detected no clinical manifestations of VEXAS.” acrjournals.onlinelibrary.wiley.com/doi/10.1002/ar…

Combining IFNAR inhibition with mRNA-LNP vaccination promoted specific stem cell-like memory T differentiation and enhanced protection against chronic infection Joanna Groom The Pardi Lab biorxiv.org/content/10.110…

For 25 years, the Toll-like Receptor pathway was considered a series of distinct protein complexes that drive inflammation. Today, we report that the entire pathway, from receptor to transcription factor, is executed from within one complex—the myddosome. nature.com/articles/s4158…

#InterferonPower! All re type I IFNs Science Immunology by CrowLab & Casanova Lab: “only a narrow window of IFN-I activity is beneficial”! Insufficient IFN-I drives life-threatening viral diseases while excessive IFN-I causes inflammatory interferonopathies bit.ly/SciImm_adm8185

.Sonja Fernbach, Mair, Ben Hale UZH Medical Virology and colleagues dissect how rare anti-IFN-I autoantibodies develop and weaken defenses over time, making some individuals more susceptible to infections. hubs.la/Q02H58D10 #Autoimmunity #Immunodeficiency #InfectiousDisease

Can we recreate the transcriptional states seen in single-cell atlas projects? In our new preprint we try to do this using large-scale Perturb-seq experiments. Along the way we discuss off-target effects of CRISPR epigenetic editors and identify drivers of key fibroblast states.

TBK1 and IKKϵ protect target cells from IFNγ-mediated T cell killing via an inflammatory apoptotic mechanism biorxiv.org/cgi/content/sh… #biorxiv_immuno

Have you ever wondered why some cell lines are easy to edit with CRISPR-mediated gene editing, while others are more difficult? Our paper is now online and offers an interesting answer: nature.com/articles/s4158…

Happy to share my first postdoc paper, out today in Nature! nature.com/articles/s4158… This started with a simple question: Can we learn more about viral proteins by looking at their predicted structures? /1

Excited to share our study of T cell signaling, where we directed high-content, single-cell genetic screening to uncover how a single adapter protein orchestrates a complex cellular process essential for health. (1/14) biorxiv.org/content/10.110…

Thrilled to share our new paper in Science Magazine, in which we identify p62/SQSTM1 as a critical regulator of micronuclei 🧬🔬🧫 #ScienceResearch science.org/doi/10.1126/sc…

CD14 is a decision-maker between Fas-mediated death and inflammation dlvr.it/TCXplX