Madelynn Whittaker (@mn_whittaker) 's Twitter Profile
Madelynn Whittaker

@mn_whittaker

Just here for the CRISPR craic ✂️ 🧬 Currently, PhD Student @pennbioeng in the Musunuru Lab || @NSF Graduate Research Fellow || @ArtisVentures Fellow

ID: 1242508312559509510

linkhttps://www.linkedin.com/in/madelynn-whittaker-a5842b103/ calendar_today24-03-2020 17:47:29

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382 Followers

240 Following

Madelynn Whittaker (@mn_whittaker) 's Twitter Profile Photo

What an amazing opportunity it was to present a poster at #ASGCT22 on our work using epigenome editing to regulate PCSK9 as a therapeutic strategy. So great to chat gene editing and CRISPR with other attendees! 🤩

What an amazing opportunity it was to present a poster at #ASGCT22 on our work using epigenome editing to regulate PCSK9 as a therapeutic strategy. So great to chat gene editing and CRISPR with other attendees! 🤩
Ben Kleinstiver (@bkleinstiver) 's Twitter Profile Photo

ABE8 PAM variant constructs constructs available on Addgene! These enzymes edit As to Gs like 🔥 + have a P2A-EGFP for cell viz. Plasmids not currently assoc. with a publication, but happy to share data as needed. addgene.org/browse/article…

Madelynn Whittaker (@mn_whittaker) 's Twitter Profile Photo

I was delighted to give my first talk of my scientific career at #ASHG22 !! It was such a wonderful opportunity to outline some of my graduate work so far: developing a CRISPR-based epigenetic strategy to regulate hPSCK9 and hANGPTL3 durably and reversibly.

I was delighted to give my first talk of my scientific career at #ASHG22 !!  It was such a wonderful opportunity to outline some of my graduate work so far: developing a CRISPR-based epigenetic strategy to regulate hPSCK9 and hANGPTL3 durably and reversibly.
Madelynn Whittaker (@mn_whittaker) 's Twitter Profile Photo

I throughly enjoyed presenting my recent graduate work at the Cardiac Regeneration & Vascular Biology Conference in Venice of TU München and Universität München! 🇮🇹 What a beautiful venue to hear more about cutting edge cardiovascular science🫀🧬

I throughly enjoyed presenting my recent graduate work at the Cardiac Regeneration &amp; Vascular Biology Conference in Venice of <a href="/TU_Muenchen/">TU München</a> and <a href="/LMU_Muenchen/">Universität München</a>! 🇮🇹 What a beautiful venue to hear more about cutting edge cardiovascular science🫀🧬
Madelynn Whittaker (@mn_whittaker) 's Twitter Profile Photo

Here’s to the future of in vivo gene editing!! Incredibly honored and excited to be part of this extraordinary, collaborative effort to develop CRISPR-based genetic therapies for these diseases 👏🏼 this is just the beginning 😎

Eric Vallabh Minikel (@cureffi) 's Twitter Profile Photo

Introducing CHARM: a new epigenome editor to methylate DNA at the promoter of a targeted gene. Our lab's collaboration with Jonathan Weissman's Lab's Edwin Neumann & Tessa Bertozzi shows deep silencing of brain PrP Paper: science.org/doi/10.1126/sc… Blog: cureffi.org/2024/06/27/int…

Introducing CHARM: a new epigenome editor to methylate DNA at the promoter of a targeted gene.
Our lab's collaboration with <a href="/JswLab/">Jonathan Weissman's Lab</a>'s <a href="/EdwinNNeumann/">Edwin Neumann</a> &amp; <a href="/TessaBertozzi/">Tessa Bertozzi</a> shows deep silencing of brain PrP

Paper: science.org/doi/10.1126/sc…

Blog: cureffi.org/2024/06/27/int…
Eric Topol (@erictopol) 's Twitter Profile Photo

What if there was a (epi-)genetic editor that could find the prion virus throughout the brain and durably silence it? There is now, in mice. With implications well beyond prion diseases science.org/doi/10.1126/sc… science.org/doi/10.1126/sc… Jonathan Weissman's Lab Eric Vallabh Minikel Whitehead Institute MIT Dept of BE

What if there was a (epi-)genetic editor that could find the prion virus throughout the brain and durably silence it?
There is now, in mice. With implications well beyond prion diseases
science.org/doi/10.1126/sc…
science.org/doi/10.1126/sc… 
<a href="/JswLab/">Jonathan Weissman's Lab</a> <a href="/cureffi/">Eric Vallabh Minikel</a> <a href="/WhiteheadInst/">Whitehead Institute</a> <a href="/MITdeptofBE/">MIT Dept of BE</a>
Edwin Neumann (@edwinnneumann) 's Twitter Profile Photo

We believe this will forge a path to a much-needed prion disease treatment, and we think CHARM could potentially be applied to other neurodegenerative diseases. Please also check out this excellent perspective piece by Madelynn Whittaker and Kiran Musunuru! science.org/doi/10.1126/sc…