Can anyone explain what mechanism is which causes aminoglycosides to be more effective against gram negatives than against positives? ID:IOTS podcasting Bug Pharmacist 💊🧫 Tim Gauthier #idtwitter Jakko van Ingen

Natuurkenners, wat is het knisperend geluid dat je tussen de bladeren op de grond hoort in het bos op een warme dag als vandaag? Ik lees vooral dingen over dennenappels, maar er stonden geen naaldbomen in de buurt. Iemand een idee? IVN Natuureducatie Staatsbosbeheer Natuurmonumenten

🤖Study describes method to prove adequate in situ disinfection & uses method to assess efficacy of a mobile disinfection robot 🦠Findings support idea that UVC robots, alongside conventional disinfection, may achieve adequate bacterial load reduction ow.ly/Yj8550Q4vaJ

Erm, how did Figure 1 get past a peer reviewer?! frontiersin.org/articles/10.33… H/T Dr Anna Young 💙

Do you ever give Bactrim for Enterococcus uti? It is something we never do, but someone told me that people do it ‘in America’, Brad Spellberg?

Latest evidence of utter failure of non-inferiority trials to set appropriate non-inferiority margins. Clinicians should ignore these margins & statistical claims of non-inferiority & instead think how their patients would balance benefits/harms/burdens. pubmed.ncbi.nlm.nih.gov/37421996/

Gus Hamilton Todd C. Lee Joshua Davis Its true of many trials in ID that we haven't powered them to find small differences in mortality like 1-3% range (as opposed to cards which has for many drugs)

Prosthetic valve endocarditis with viridans streptococcus with penicillin MIC of 0,75. eGFR of 35. So prefer not to use gentamicin. How would you treat? Penicillin 18 mil. U/day? Ceftriaxone 2g/day? Or different? #IDTwitter Brad Spellberg Kyle Walding Gus Hamilton Luke Turner 🦠

Someone mentioned the quote by the US surgeon general that infections were a thing of the past today, so I googled it, and I was pleasantly surprised to find your myth-debunking article as the first result Brad Spellberg ncbi.nlm.nih.gov/pmc/articles/P…

"I suggest that Dr. Bik Elisabeth Bik abandon this approach of hunting for mistakes in our or other people's work because it leads to unfounded accusations, but I suspect she and/or her assistants will find new arguments and tweet about extensively..." pubpeer.com/publications/0…

Is there data on the diagnostic utility of cloudy or flaky urine for diagnosing UTI? It is often used by non-ID as an argument for starting treatment, but I have never heard a microbiologist/ID physician use it as for support for diagnosis. Brad Spellberg Todd C. Lee ID:IOTS podcasting

We were discussing today, has amoxi+ceftriaxone synergy really been proven Brad Spellberg? The source that you refer to refers only to experimental models. I wonder if there is any good clinical data. Do you know?