Follow the fluid: new #URochesterResearch from NedergaardLab sheds light on connection between auras and migraines, points to new drug targets. Via Science Magazine👉urmc.info/1DD urmc.info/1DE

Years ago Martin Rasmussen was on a Fulbright studying meningeal afferents in my lab & noticed dyes placed in CSF accumulate in trigeminal ganglia. This observation nucleated his PhD project in NedergaardLab & has now led to a new model of migraine pain. science.org/doi/10.1126/sc…

For millennia, migraine's origin puzzled scientists. We contributed to the Science Magazine paper showing how cortical spreading depression alters 11% of CSF proteome, including 2-fold increase in CGRP. The proteomic shift may explain aura-headache link. Nicolai J. Wewer Albrechtsen NedergaardLab

🏖️ Summer vacations are perfect for catching up on sleep! 💤 Discover why sleep is crucial for our brains through Maiken Nedergaard's pioneering work on the glymphatic system. Watch her fascinating #HFSPNakasone lecture: youtu.be/f7IcZag6loY #SleepScience NedergaardLab

A new Science study in mice identifies a novel non-synaptic signaling mechanism between the brain and peripheral sensory system important for migraine. Learn more ⬇️ 📄: scim.ag/7D5 #SciencePerspective: scim.ag/7D4

Really nice review discussing the anatomical and functional evidence for the SLYM layer. anatomypubs.onlinelibrary.wiley.com/doi/10.1002/ar…

Virally Induced CRISPR/Cas9-Based Knock-In of Fluorescent Albumin Allows Long-Term Visualization of Cerebral Circulation in Infant and Adult Mice link.springer.com/protocol/10.10…| Marta Vittani, Philip Aleksander Gade Knak, Masahiro Fukuda, Masaki Nagao, Xiaowen Wang, et al.

Online now! Cervical lymphatics drain CSF and clear metabolic waste from the brain. Du et al., show using 2P-OPTIC that these are disrupted in aging due to reduced pumping. Restoring cervical lymphatic function with PGF2a rescues brain clearance. doi.org/10.1038/s43587…

Beautiful paper from NedergaardLab in Nature Aging on the role of cervical lymphatics in cleansing of aged brain. Glymphatics/meningeal lymphatics = bff 🤩|| nature.com/articles/s4358…

#URochesterResearch via Nature Aging shows how scientists restored the brain’s ability to clear toxic waste in older mice with a drug that's currently used to induce labor. This points to a potential new treatment for #Alzheimers and #Parkinsons. Paper: go.nature.com/46WCR8F

New cool data on the impact of aging on cervical lymphatic vessels in Nature Aging – and how a prostaglandin can restore function. nature.com/articles/s4358…

Oxygen sensor for in vivo expression available now on Addgene: AAV vector expressing GFAP-GeNL addgene.org/221455/ NedergaardLab

Why sleep is important! biorxiv.org/content/10.110…

2 years of postdoctoral fellowship in Translational Neuroscience completed today. Grateful for the opportunity BRIDGE - Translational Excellence Programme & Novo Nordisk Foundation. I thank my excellent mentors, Prof. Maiken Nedergaard & Prof. Messoud Ashina NedergaardLab Human Migraine Research Unit UCPH Healthscience #migraine