Machine learning prediction of prime editing efficiency across diverse chromatin contexts go.nature.com/3VQNmq9

If you want to know the outcome of your prime editing experiment before you even conducted the experiment, visit pridict.it Congrats to Nicolas and many thanks to all collaborators Krauthammer Lab Bas van Steensel lab

Our new sensor for the neuropeptide #nociceptin is now out in Nature Communications Fantastic teamwork with the mbruchas lab and many other super collabs! Very proud of our student Xuehan for her PhD work! Check it out: rdcu.be/dLO3m 😉

Thrilled to see our click editing paper out today in Nature Biotechnology! 🚀 Click Editors (CEs) are a new class of genome writers which combine DNA polymerases and HUH endonucleases with RNA-programmable nickases for precise edits without DNA DSBs🧬✨ nature.com/articles/s4158…

Bridging genome editing, protein engineering, and applied machine learning in biology: Great to see our latest study, spearheaded by Kim Fabiano Marquart, out today in Nature Methods. Check out the paper! 🧬💻 UZH Science Gerald Schwank Krauthammer Lab nature.com/articles/s4159…

TnpB is much smaller than the well-known CRISPR-Cas "gene scissors". The tool for targeted modification of the genome has now been improved to such an extent that it could one day be used to treat a genetic defect that leads to a lifelong high cholesterol level.

Our TnpB story has been published in Nature Methods 🚀 Check out the thread by Gerald Schwank to dive right in.

If you're more of a visual learner, this explainer video is for you 🙌

Check the Nature Methods research briefing associated with our latest study on TnpB for effective genome editing nature.com/articles/s4159…