This cryptic pocket has a function! The VP35 protein from Ebola virus performs multiple functions. We wanted to know if it toggles between different conformations that are responsible for different functions. It does! biorxiv.org/content/10.110…

The lab is excited to welcome WashU Biochem, Biophys, and StrucBio PhD Program graduate student Maria Broering Maria Broering to our lab for her first rotation. Maria will work with Hannah Pletcher to explore various aspects of mitochondrial metabolism. Welcome, Maria!!

My first op-ed is out! Starting my faculty career was challenging in many ways, and one of those is that I had a leadership job that I didn't expect and wasn't (really) prepared for. Thanks to Inside Higher Ed for the chance to write about this and share some advice!

I dare say, this is probably single most accomplished contribution to plant structural biology field in at least a decade. Back to back Cell papers by Zhen Yan lab Westlake University report structures of a plant chloroplast import complex TIC-Ycf2-FtsHi & algae Ycf2-FtsHi.

Woohoo, our paper on the mechanism of a G protein inhibitor that is specific to one family of G proteins is out! Nice collab with the Blumer nad ASoranno labs pnas.org/doi/10.1073/pn…

🚨 New paper alert from @martenssascha!🚨 We explore how transmembrane cargo receptors initiate selective autophagy. Through biochemical reconstitutions, we discover a new autophagosome biogenesis pathway with implications for therapeutic interventions. biorxiv.org/content/10.110…

Thrilled to share our latest story Nature Cell Biology on a new way to control protein localization without exogenous triggers (e.g., light/rapamycin)—take advantage of endogenous triggers in dividing cells! Free link: rdcu.be/dSlrS Regular link: nature.com/articles/s4155… 1/4

🔬 Curious about #mitochondria #imaging but unsure where to begin? Our review might help! Now on early publication Annual Reviews🚀📜 doi.org/10.1146/annure… Kleele lab Suliana Manley 🔬🗜🧫 Willi L Stepp #Quantitative #Microscopy #SuperResolution #CellBiology

I'm on the job market looking for faculty positions! If you want to talk about protein dynamics, precision medicine, drug resistance, and/or puppy photos, reach out!

New preprint! Precious C. Opurum utilized our recently developed model of mouse sedentary behavior to study its influence on chronic kidney disease. biorxiv.org/cgi/content/sh…

1)❗️FUNDING OPPORTUNITY HERE❗️ Let us dive into our latest initiative, the student proteomics fund (SPF). A 5000 EUR fund that will be awarded to an outstanding proteomics project conceptualized by a young scientist

We are happy to announce that Rhythmidia, a modern tool for analyzing circadian phenotypes in race tube assays, is out in PLOS Comp Biol. Led by the talented Alex Keeley!! doi.org/10.1371/journa… (fig1) 🧵1/6

Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳 Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!  biorxiv.org/content/10.110…

Mitochondrial ATP synthase dissected in situ! 6 distinct states of the central stalk with 21 substates, some never seen before. Mito structural biology feast! Brilliant work by Lea Dietrich Ahmed-Noor A. Agip Andre Schwarz from Werner Kühlbrandt's lab Max Planck Institute of Biophysics science.org/doi/10.1126/sc…

Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism dlvr.it/TCvcsl

As we start the new academic year, the lab is excited to welcome Srikar Vegesna, an undergraduate WashU that will work with Tessa Lochetto to study mitochondrial function in striated muscle. Welcome, Srikar!

Christian, thank you for sharing your wisdom 🙏🏼 Must read for all scientists! And, if you’ll humor me, I’d like to highlight three points. 1) There are limitless ways to be a success. Don’t let someone else’s version of success diminish these other paths! And for that matter,

Happening next Tuesday! You won’t want to miss our first speaker of our fall series. Natalie Niemi is sure to give a great talk to kick off the semester! Can’t wait. Morgridge Institute Discovery Building Tim Rhoads

Congrats to all the ⁦WUSM Biochemistry and Molecular Biophysics⁩ award and fellowship honorees. The future looks bright!