Very proud to see this work finally in print, 3.5 years after a first version on bioRxiv 😅. A tour de force by Raffaella Gallo and Arpan Rai with support from Alexa McIntyre and Katrina Meyer. cell.com/developmental-…

Excited to share a fun collaboration w/ Stephen B Montgomery & Ana Cvejic! Using the largest single-cell dataset of fetal hematopoiesis in Down Syndrome to date, we asked: Why is trisomy 21 associated w/ both elevated leukemia risk + red blood cell abnormalities? biorxiv.org/content/10.110…

So excited to announce that my most recent work has been published. If you’re interested in genetically encoding circular mRNA, or packaging circular mRNA into virus-like particles for cell-type specific delivery, this paper is for you!

The MLY(narczyk) lab👩‍🔬is opening at Yale University this July! Excited🎉to explore immuno-metabolism in germinal center-derived B cell malignancies🦠🦀. Recruiting trainees at all levels, please RT/DM/email if interested or for recs. Our latest: urldefense.proofpoint.com/v2/url?u=https… 1/3

Had the best time chatting with Daniel Garalde about the fun I've had looking at single-cell isoforms, and as always at the end of the day there's more questions than answers 🧠

Thrilled to share our latest work out now in Science Magazine demonstrating a heterozygote advantage at HLA-II in protecting against lung cancer risk in smokers! Check out Diego Chowell’s tweetorial below👇

Very excited to share our new paper on how mutations in SWI/SNF chromatin remodeling complexes alter chromatin dynamics and immune cell-fate to drive lymphoma, online now in Cancer Cell. authors.elsevier.com/c/1ijJ05TA51hO… More details in the thread below.👇 🧵 1/n

The covariance environment defines cellular niches for spatial inference go.nature.com/4auQI72

Our #BICCN paper is out at Nature Neuroscience Led by Anoushka+Wen Hu. Single-cell isoforms across brain regions,development&species. nature.com/articles/s4159… #LongRead #RNA iRNA_COSI #nanopore #pacbio #genomics #Transcripomics #RNAseq #Splicing Thank you Elisa Floriddia !

Researchers use cutting-edge sequencing methods to build the most comprehensive atlas of mRNA variants in the brain. The study, led by Dr. Hagen Tilgner of WCM Brain and Mind Research Institute and Dr. Anoushka Joglekar, may help us better understand brain function and disease. bit.ly/4arHE2P

Single-cell long-read sequencing-based mapping reveals specialized splicing patterns in developing and adult mouse and human brain nature.com/articles/s4159…

GoT-ChA! I am thrilled to announce that our paper "Mapping Genotypes to Chromatin Accessibility Profiles in Single Cells" is now out in nature !! 👩‍🔬👨‍🔬🧬If you want to link somatic mutations to epigenetic changes directly in patient samples: nature.com/articles/s4158… 👇🧵

Fantastic first innovation day at London calling Oxford Nanopore Events. I'd say forgetting to tweet = sign of good times

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In today's Cell, we propose a “developmental constraint” model whereby cancer cell state plasticity is restricted by the organism’s developmental map to access progenitor-like states and differentiated-like states of adjacent lineages.🧵⬇️ sciencedirect.com/science/articl… Ayushi Patel