A high-resolution view of how replication-coupled DNA breaks are generated, processed and repaired. Congrats to Raphael Pavani, Veenu Tripathi, and many terrific collaborators including Johannes Walter, Cejka Lab, Wei Wu. See science.org/doi/epdf/10.11…

So, so honored to be included in this group of such inspiring scientists!

Delighted to announce that our postdoctoral fellow, Sehbanul Islam, has been awarded the Rising Star Award from the CHOP Research Institute Normal and Malignant Hematopoiesis Research Affinity Group for his outstanding research and publication. Congratulations🥳 Sehban

World's Most Breathtaking Castles Let's journey to an era of knights, chivalry, and grandeur. (thread 🧵) From medieval fortresses to fairy-tale palaces—let's explore:

🌟Exciting News!🌟 We are thrilled to share that our recent paper has been published in Nature Communications! Our findings reveal that DCAF15 controls cohesin complex recycling and preserves replication fork integrity to sustain AML cell proliferation. nature.com/articles/s4146…

Branched #ubiquitin has important roles in cell signaling but are very challenging to study due to complexity & lack of tools. We tackle this challenge in our latest study NatureStructMolBiol developing a toolkit enabling discovery of molecular players and pathways rdcu.be/dM5nn

“We are going to kill ourselves because of stupidity.” ~ Allan Savory

We identified a complex network of proteins that regulate MMEJ:NHEJ repair pathway balance in a chromatin context-dependent manner. With impact on cancer genomes. Paper is finally out: nature.com/articles/s4146…

U.S. News & World Report released their latest rankings of hospitals for 2024-2025 and we are excited to share that NYU Langone Health is home to the most top 10-ranked specialties in New York. Learn more about the rankings: nyulangone.org/news/nyu-lango…

Our plasmid collection of 98 human DNA mismatch repair genes and their regulators is now available through Addgene, together with another >200 plasmids from our lab. We hope they will be useful to the scientific community see: addgene.org/browse/article…

Check out our latest review regarding the biology of RAS GTPase effectors! It was fun to write this with Alessandro Mozzarelli and Simanshu Dhirendra for Molecular Cell. Bottom line: lots of knowledge on these proteins, but many questions that remain to be answered. cell.com/molecular-cell…

Double feature today - this first one from Georg Winter and colleagues identifies a broad swath of kinase inhibitors that are also degraders, via diverse mechanisms all unified by driving an endogenous degradation pathway. 1/3 biorxiv.org/content/10.110…

Next is this related paper from the Winter and Waldmann labs showing a similar phenomenon for IDO1 - and an indicator that the effect is not limited to kinases. 2/3 biorxiv.org/content/10.110…

CRI is proud to share the new cohort of Lloyd J. Old STARs! Meet the researchers who will receive $1.25 million over 5 years to drive high-risk, high-reward projects with the potential to transform cancer treatment and advance the frontiers of the field: bit.ly/3YAZIVd

I am deeply honored to be named one of this year's recipients of the prestigious Lloyd Old STAR grant of the Cancer Research Institute . To be included in the esteemed list of previous and current awardees is humbling and inspiring. I am grateful for this incredible opportunity🙏

A new study led by researchers at NYU Langone Health and Perlmutter Cancer Center at NYU Langone Health identified a gene signature that one day may serve as a biomarker of severe side effects from immunotherapy for #melanoma. Clinical Cancer Research Learn more about the study: aacrjournals.org/clincancerres/…

A fireside chat with free thoughts, reflections, and memories frontiersin.org/journals/cell-…

Excited to share our latest work combining VHL and CRBN in a single trivalent PROTAC to boost protein degradation. Great #TPD collaboration with Georg Winter and Kristin Riching, led by Adam Bond Miquel & Celia in each lab Centre for Targeted Protein Degradation CeMM Promega Corporation doi.org/10.26434/chemr…

I am beyond thrilled to share my first co-first paper. We defined the role of RAD51/BRCA2 in protecting Abasic sites from MRE11 cleavage. ssDNA gaps, POLtetha, Cryo EM of RAD51 binding AP sites and much more!! cell.com/molecular-cell…

USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination biorxiv.org/cgi/content/sh… #biorxiv_cellbio