How much human knowledge has been lost to history?

Well, this ancient wonder was razed by the Mongols in 1258 — it's said the Tigris River ran black with ink.

Here's what was inside... (thread) 🧵

Emerging threats: Is highly pathogenic avian influenza A(H5N1) in dairy herds a prelude to a new pandemic? sciencedirect.com/science/articl… via Francesco Branda et al

Oh wow, this is a doozy of misrepresentation of cancer statistics - let us go through their claims and see what the evidence actually shows. Spoiler alert: there is an ongoing trend of increased cancer in young people (<50 years-old) since the mid-90s that is continuing.

Subclinical Atherosclerosis to Guide Treatment in Dyslipidemia and Diabetes Mellitus link.springer.com/article/10.100… via Reed Mszar et al

What derek guy fails to take into account in his threads on tailoring are the sage words of my brother-in-law:

“Every man is one hotdog away from not fitting into his suit.”

The placebo effect: powerful, powerless or redundant? bjsm.bmj.com/content/47/1/6 via Steve Kamper

Cost and value of cancer medicines in a single-payer public health system in Ontario, Canada: a cross-sectional study thelancet.com/journals/lanon… via Bishal Gyawali et al

The NHS needs better management and more (especially operational) management capacity; fewer, better, more focussed goals; clearer incentives; and a system that focussed on getting things done rather than telling people what to do.

Today's #IntegrityInertia 's paper.
Reported to @Wiley's Journal of Applied Microbiology (now Oxford Academic) in October 2015.
No action was ever taken.
Instead, Oxford Academic wants you to pay $51 for 24h access to this crap.
pubpeer.com/publications/9…
academic.oup.com/jambio/article…

Get rid of political interference in the NHS , you decide the budget then leave the NHS to manage that budget independently. Go on , we dare you to think differently 🙏

Seven types of research gaps

Preventive PCI: the pitfalls of preventive cardiology

On Patient Safety: Shoulder “Impingement”: Telling a SAD Story About Public Trust journals.lww.com/clinorthop/ful… via Teppo Järvinen

Epitome of overtreatment in our orthopaedics field is the continuing use of low-value ops such as arthroscopic partial meniscectomy for degenerative meniscal tears and arthroscopic subacromial decompression for shoulder impingement. journals.lww.com/clinorthop/ful… via Aleksi Reito

Recognize the Value of the Sum Score, Psychometrics’ Greatest Accomplishment link.springer.com/article/10.100… via Denny Borsboom et al

‘Privileged access’: pro-plastic lobbyists at United Nations pollution talks increase by a third theguardian.com/environment/20… via Sandra Laville

Effect of combo Rx w/ glucagon-like peptide-1 receptor agonists & sodium-glucose cotransporter-2 inhibitors on incidence of CVD and serious renal events: population based cohort study bmj.com/content/385/bm… via Laurent Azoulay et al Swapnil Hiremath @[email protected] ChristosArgyropoulos MD, PhD PharmanukerInChief SABOURETCardiologist

Understanding trauma as contextualized adverse life events that threaten the individual: Commentary in response to Marx et al. (2024) onlinelibrary.wiley.com/doi/full/10.10… via Philipp Herzog

Risk of bias of prognostic models developed using machine learning: a systematic review in oncology ncbi.nlm.nih.gov/pmc/articles/P… via Paula Dhiman et al

Justin Hensley Thomas Shanahan (Dr.) MRCEM Amit Ganguly This might be some of the best evidence we have, but worth noting it’s pre-hospital and the studies were deemed either low quality or very low quality. Also, most CICO situations Im personally familiar with weren’t elective and ultimately required a definitive airway(1/2)