Women are under-represented at senior levels in #academia globally, and across all #science disciplines, as shown by these "scissor-shaped curves" ✂️ So how can we achieve #gender #equality? We discuss various strategies in this #Cell Commentary.. 🧵 cell.com/cell/fulltext/…

- Parental leave support to hire a technician - On campus childcare - Grants for transition to independence - Transparent faculty hiring procedure - Training to avoid implicit bias - Leadership courses, networking - "Help platform" to counteract harassment - and much more ⬇️ 6/

Our lab's first preprint bioRxiv is out! We discovered that high affinity chimeric antigen receptor (CAR) signaling induces an #inflammatory program in #human regulatory T cells (Tregs)! 🧵 #immunologymatters #changingwhatspossible #CARTregs 🚗🦖 biorxiv.org/content/10.110…

Some clever T cell engineering going on here.

One of my main motivations for founding Our World in Data was to overcome the mad reality in academia that much of the most important research and data is locked away behind paywalls. I wanted research and data to be a public good, accessible to *everyone*. If you find our work

Capiche?

Thanks for sharing our paper on the very low risk of T cell malignancies driven by insertional mutagenesis in a paediatric/young adult CART setting. Impt to contrast with the non-negligible risk of secondary myeloid malignancies seen with CART as with any anti-leukaemic therapy…

JUST IN! 2004 mouse study confirmed in humans (phase II trial): polyclonal regulatory T cells (#Tregs) DO NOT cure type 1 diabetes! #immunologymatters science.org/doi/10.1126/sc… rupress.org/jem/article/19…

🩷Quino

How many academic papers are written with the help of ChatGPT? To answer this question, we analyzed 14mln PubMed abstracts from 2010 to 2024 and looked for excess words: ** Delving into ChatGPT usage in academic writing through excess vocabulary ** arxiv.org/abs/2406.07016 1/11

We are continuously trying to facilitate the manufacturing of gene edited CAR T cells. Here a cool collab with Indee labs using hydroporation to gently deliver Cas9 RNP and move of away from electroporation.

Brilliant CAR engineering strategy, beautiful data presentation, and compelling storytelling.

I will be in Porto, Portugal, July 4-12, meeting some other science image sleuths, and giving a talk at Universidade Porto. Any journalist or other folks interested in meeting some of us?

Very disappointed to find that Vance Refrigeration is not trending right now.

YES PLEASE

Big Nature paper this week on improved lifespan (in mice!) using an antibody to block IL11 Old mice without IL11 even look healthier 🧵

The 10 biggest medical research papers from this week (in my opinion!) 1. The mTOR inhibitor, Rapamycin, extends lifespan in healthy mice, as does the MEK inhibitor, Trametinib Combining both together boosts mice lifespan by ∼30% biorxiv.org/content/10.110… 🧵

TP53: - Discovered 45 years ago, most cited gene all time - No therapies - 500 million people currently living will die of TP53 mutant cancers without new therapies Our Preprint: - A general strategy for TP53 missense mutant cancers (majority) with prototype small molecules

NaCl enhances CD8+ T cell effector functions in cancer immunotherapy nature.com/articles/s4159…

Yes. CNS are just like the Oscars. It's well know that filmmakers pay the Academy $10b a year to supervise the process, lets voters tell directors to reshoot with a list of 10 new scenes they must add, and the Academy owns the films at the end of the process.