Cool to see Qatar Biobank investments paying off!

Akl Fahed @injeon_shim and I wrote about this in a previous edition of Genome Medicine

…medcentral-com.treadwell.idm.oclc.org/articles/10.11…

Endogamy and consanguinity increase discovery potential in these cohorts.
cc: OurHealth PRIMED Consortium

1/12 - Mystery #1

You are seeing a patient recently diagnosed with heart failure and started on GDMT. You notice that their hemoglobin (HGB) has increased (12 → 13 g/dL) in the intervening weeks.

🤔Which medication is the likely cause of this increase in HGB?

Poor communication between healthcare professionals and patients has a strong influence on health outcomes. This is particularly an issue in India 'where health care walks hand in hand with superstition, myths and luck' nytimes.com/2024/04/12/opi… New York Times Opinion by Vidya

Genetic variation is relatively poorly studied in the Middle East, particularly where endogamy and consanguinity are more common. Among 6K WGS in Qatar, 2 in 3 (!) was a carrier for a pathogenic mutation for an autosomal recessive condition. link.springer.com/article/10.118……

If like me, you missed this fantastic #HYPHIP chat yesterday with authors So Mi Jemma Cho and Pradeep Natarajan, just search for #HYPHIP and you can follow the conversation. Moderated by the great Francisco Rios! 👇🏽👇🏽👇🏽 Hypertension

If due to time zone differences🙋‍♀️you missed our Hypertension #HYPHIP Chat with So Mi Jemma Cho Pradeep Natarajan & Francisco Rios on the important🔦of isolated diastolic #hypertension then please follow #HYPHIP 🧵

Congratulations again to the authors for this impt contribution to the field👏👏

Excellent work by Mohammad Saadatagah Mohammadreza Naderian M Mesbah Uddin Iftikhar J. Kullo Pradeep Natarajan BCM Cardiology BCM_CVRI Na Li (李娜) Lab BCM Department of Medicine #aging #cardiovascular

MGH Cardiac Lifestyle Program has been working on lifestyle interventions for weight loss with Jeff Ashburner and EPs like #aneeshbapat and Moussa Mansour

Now integrating GLPs is the next step!

ncbi.nlm.nih.gov/pmc/articles/P…

Mass General Heart

Francisco Rios Hypertension [1/2] Thank you Francisco Rios, Hypertension #HYPHIP editors and readers for this rare opportunity! This work was enabled by Pradeep Natarajan, Hokyou Lee, MD, PhD Satoshi Koyama Roger Zou Art Schuermans Shriie Ganesh Whitney Hornsby Michael Honigberg, MD, MPP and MGBB participants!

Please join us for a #HypHIP Live Author Chat Hypertension with Dr So Mi Jemma Cho So Mi Jemma Cho Pradeep Natarajan

~ In less than 1h (14:00-15:00 UTC).

Lets discuss about Cumulative Diastolic Blood Pressure and Cardiovascular Disease.
Article below: ahajournals.org/doi/10.1161/HY…

Nice 🧵 by Romit Bhattacharya 👇

🎯Hypertension timely AHA Science discussion & please join our Live Chat tomorrow👇on Cumulative Diastolic #BloodPressure burden in normal SBP & #CVD

Congratulations🌟🌟 #HYPHIP au So Mi Jemma Cho & Pradeep Natarajan with our #SoMe Editor Francisco Rios

We studied the association of CHIP and AF and investigated the potential intermediates.

jamanetwork.com/journals/jamac…

Mohammadreza Naderian M Mesbah Uddin Ozan Dikilitaş, M.D. Art Schuermans Liz Selvin vijay nambi Alex Bick Michael Honigberg, MD, MPP Na Li (李娜) Lab Pradeep Natarajan Iftikhar J. Kullo Christie Ballantyne

Good to see that this is finally out! A full thread is loading

Results of this cohort study show that large TET2 and ASXL1 CHIP—but not DNMT3A CHIP—were associated with higher IL-6 level, indices of cardiac remodeling, and an increased risk for AF. ja.ma/3VOzLAf

Vertex to buy Alpine Immune Sciences for $4.9 billion statnews.com/2024/04/10/ver…

From me and Adam Feuerstein ✡️

Vertex plans to buy Seattle-based Alpine Immune Sciences—$4.9B in cash incl investigational drug entering Phase 3 that's shown promise in treating IgA nephropathy, autoimmune disorder of the kidney that can lead to end-stage renal disease & affects 130,000 people in US $ALPN…

New work led by Mohammad Saadatagah Mohammadreza Naderian in JAMA Cardiology underscores that not all CHIP 🩸🧬 is the same. TET2 CHIP assoc'd w/ ⬆️ IL-6 and AF risk, esp when clones are large.

jamanetwork.com/journals/jamac…

Art Schuermans Alex Bick Pradeep Natarajan Iftikhar J. Kullo Christie Ballantyne

Fantastic characterization of 67K Lp(a) tests among 51K patients over 23 years in Mass General Brigham.
Kudos to Christian Faaborg Andersen MD So Mi Jemma Cho Michael Honigberg, MD, MPP for digging up all of the various Lp(a) tests performed in MGB to now be among the largest clinical Lp(a) registries. #ACC24 …