Every repeat is unique: Exploring the genomic impact of human L1 retrotransposons at locus-specific resolution dlvr.it/T2rGbP

Targeted degradation of extracellular and membrane proteins is being pursued with therapeutic platforms including sweeping antibodies, LYTACs, ATACs, AbTACs, PROTABs and KineTACs - find out more in this review in the February issue bit.ly/489BXVZ rdcu.be/dtT1P

Excited to see our paper "Decoding Chromatin States by Proteomic Profiling of Nucleosome Readers" out in nature! rdcu.be/dAv5S Explore our data on how epigenetic modifications modulate protein binding to chromatin with MARCS marcs.helmholtz-munich.de Details below 👇

Very excited to share our new paper on how mutations in SWI/SNF chromatin remodeling complexes alter chromatin dynamics and immune cell-fate to drive lymphoma, online now in Cancer Cell. authors.elsevier.com/c/1ijJ05TA51hO… More details in the thread below.👇 🧵 1/n

慶應薬学部とがん研究所でセミナーをしてきました。新しい繋がりも出来たし、実りある出張でした

今度のイギリス出張高くなりそう。大台突破してしまう🥲

Updated: 🧬DNA repair/genome stability conference calendar🧬 Now includes 2024/25 meetings. Please send a reply if you have another meeting to suggest: docs.google.com/spreadsheets/d…

So incredible Isaac went from cloning of subunits to major insights into Pol II termination by INT! Watch the movie.

A new discovery from the lab bit.ly/3U6yYcM by Shimaa Soliman defines the CDK9-complex required for proper transcriptional response to hypoxia & uses of our elongation inhibitor iPAF1C to control hypoxic transcriptional elongation response Northwestern Feinberg School of Medicine PNASNews

Online Now: Time-resolved profiling of RNA binding proteins throughout the mRNA life cycle dlvr.it/T5GfWv

Natural antisense transcripts as versatile regulators of gene expression go.nature.com/4aUxisa #Perspective by Andreas Werner, Aditi Kanhere, Claes Wahlestedt & John S. Mattick Newcastle University University of Liverpool Miller Medicine UNSW

Back to Oxford😙

A high-resolution view of how replication-coupled DNA breaks are generated, processed and repaired. Congrats to Raphael Pavani, Veenu Tripathi, and many terrific collaborators including Johannes Walter, Cejka Lab, Wei Wu. See science.org/doi/epdf/10.11…

I am excited to share this story led by Yujing Cheng and Siwen Wang (not on X) in Cell which describes a new function for a small nucleolar RNA (snoRNA) in senescence and ribosome biogenesis. Read on for a brief 🧵1/ cell.com/cell/fulltext/…

Decoding protein–RNA interactions using CLIP-based methodologies go.nature.com/3zAQPAy #Review by Joy S. Xiang, Danielle M. Schafer, Katherine L. Rothamel & Gene W. Yeo Gene Yeo’s Lab at UC San Diego Free to read here: rdcu.be/dNdwp

Four-year fully-funded #PhD project on #epigenetic control of transcription dynamics in my Lab IMBB AMU Poznań with 3 month placement abroad! #3Dchromatin and #transcription with genomics & super-res microscopy! Narodowe Centrum Nauki funded. RT please! Apply till 20th Aug: storage.googleapis.com/big_wigs/PhD_G…

Our lab (papantonislab.eu) is still looking for a PhD candidate with a strong computational biology background and a keen interest for genome assembly and #3Dgenomics to join our subproject in the exciting EvoREST initiative on genome evolution. Universitätsmedizin Göttingen (UMG) Uni Göttingen

The breast cancer drug market tinyurl.com/3nbu6jev Major-market sales of breast cancer drugs totalled ~$28 billion in 2023, driven by CDK4/6 inhibitors and HER2-targeting agents. Find out more about leading products and emerging therapies in this new analysis