Pourya Naderi Dr. Ying Zhang Nature Immunology Many years of hard work to reveal a potential achilles heel for tumor initiation. Congrats to Dr. Ying Zhang and Pourya Naderi

Excited to share a manuscript out online today nature.com/articles/s4159…, which we had a supporting role for (as Judy Lieberman is NOT). The manuscript found that emerging tumor repression of immune recognition is reversed by inhibiting DNA methylation. A forthcoming synopsis:1/18

Our work offers a better understanding of the critical role of innate immune signaling in shaping tumor immunogenicity, highlighting the importance of targeting innate immune pathways for boosting anti-tumor immunity and immunotherapeutic efficacy.nature.com/articles/s4159…

8. Tumours methylate their DNA to alter gene expression and evade immune detection If DNA methylation is reversed - using decitabine (DAC) - the immune system is re-activated, and tumours regress (in mice!) nature.com/articles/s4159…

Study reveals how #cancer outsmarts immunity—and how to potentially turn the tables @bidmchealth @natimmunol medicalxpress.com/news/2024-08-r…

Happy to share our new paper in Nature Neuroscience from the BioFINDER ‼️ We looked at Olink Proteomics in relation to Abeta and tau-PET across the #Alzheimers continuum, and compared to patients with non-AD neurodegenerative diseases! nature.com/articles/s4159…

We first saw evidence for this ~ 2019. We were super surprised & skeptical. After 5 years of quintuple cross-validation, we feel confident to share with the world.

miR-29 is a driver of aging-related related phenotypes: rdcu.be/dR6ib. Pleased to share this study, which reflects a long-standing collaboration with DeshmukhLab Emilie Hollville ♻️🏳️‍🌈🏳️‍⚧️ and others UNC Neuroscience Center, who started the work. Cornell University Cornell University College of Veterinary Medicine Matt Kanke Amy YH Hung

Using #scRNAseq and preclinical models of #BreastCancer in a study funded by our division, Winston hide BIDMC et al. showed that tumors edit genes via epigenetic mechanisms to escape the immune system Nature Immunology nature.com/articles/s4159….

Very helpful! But consider colorblind-friendly color palettes 🎨 ggpubfigs only supports colorblind-friendly color palettes, so it is something users don't even need to think about :D github.com/JLSteenwyk/ggp… x.com/tangming2005/s…

How tumors go in stealth mode. Read our digest here 👉 bit.ly/3MvoRcy  Boston Children's  BIDMC Pathology  Harvard Medical School

Our paper is out! Automatic ploidy prediction and quality assessment of human blastocysts using time-lapse imaging .. congratulations to my star PhD student and first author Suraj Rajendran Tri-I CBM Weill Cornell GSMS WCM Englander Institute for Precision Medicine Weill Cornell Medicine nature.com/articles/s4146…

Everybody’s favorite voluntary org at BIDMC! Truly a delight to work with these group of amazing people!