Created with content from our Best of CAR T at #Tandem24 webinar series, this infographic features key insights on the biology of relapse after transplant and cellular therapy. View the full series of infographics: ow.ly/wcGC50T6EHQ

#SOHO24 Levis: multiple clones of FLT3-ITD can coexist. Some may be present at low VAF at any given time and some emerge as dominant clone later in course of therapy. Those with multiple FLT3-ITD clones appear to do worse.

#SOHO24 Hourigan: ELN guidelines are standard bearer for MRD assessment in AML. Potential uses for MRD include not only prediction of relapse but also, eg, selection of cond regimen for HCT. It remains to be shown that MRD based interventions lead to clinical benefit. #leusm

#SOHO24 Hourigan: considerations for potential uses of MRD as regulatory endpoint in drug dev. Using as a 1) means to address an unmet need that’s 2) like to be beneficial are likely routes. Using as a validated surrogate is the highest bar which will take more work/time.

#SOHO24 Hourigan: Pre-MEASURE analysis of PB FLT3 or NPM1 MRD by NGS pre-HCT showed value for predicting risk of post-HCT relapse. Validated the finding using commercially available FLT3 Invivoscribe assay.

#SOHO24 Pratz: takes up to 7 cycles to achieve flow MRD negative CR with Aza/Ven (from VIALE-A).

#SOHO24 Craddock: AlloHCT assoc w improved OS in >60yo with AML. “The question show not be which pts should go to HCT but which pts should NOT.” PTCy further improving GRFS outcomes in older pts. (UK addressing ATG vs PTCy question which wasn’t addressed by BMTCTN 1703)

#SOHO24 Craddock: evidence supports use of sorafenib or gilteritinib (in MRD+) maintenance for FLT3m AML post -HCT. Ongoing studies are addressing role for post-HCT maintenance with oral Aza (UK) or Aza/Ven (VIALE-T)

#SOHO24 Jayakumar (PGY2 at the podium 👏🏻): a nationwide analysis of aspirin effects in leukemia patients. Looked at >1.6M leukemia hospitalizations, 11.2% on ASA. ASA assoc w lower risks or VTE and, interestingly, bleeding and septic shock and shorter length of stay.

Doxorubicin plus Trabectedin followed by Trabectedin maintenance for leiomyosarcoma shows OS benifit vs doxorubicin alone . Median OS Improved from 24 months to 33 months NEJM See the post progression therapy for both arms ( 36 % of control arm got Trabectedin on

Never words , so meaningful 🙏🏻🙏🏻 thanks for sharing Archit Pandharipande !!

🙂 Happy to get the Second Place Poster Session Award at #SOHO2024 on ➡️ Venetoclax added to HyperCVAD-Nel-PegAsp In T-cell ALL/LBL: Phase 2 study MD Anderson Cancer Center Hagop Kantarjian,MD G Garcia-Manero

Last few days to apply for Indian Precision Oncology Gurukul , 2024 !! Medical Oncology Fellows and early careeer faculty , we have received several very high quality applications , very few slots left for meritorious ones ! Go ahead and click the link now and apply If you

Dr John Seymour giving Dr Michael Keating plenary award lecture at #SOHO24 Society of Hematologic Oncology (SOHO) First patient ever treated with venetoclax (previously called ABT-199) was in June 2011 in Australia with Dr Seymour. Amazing how this drug has changed the practice of leukemia care,

🚨Talk of the day: “Early vs late CAR-T in Myeloma.” No consensus reached but both sides up a notch w life qoutes, sports & music references! “Just bc you can do something doesn’t mean you should do it” Saad Z. Usmani MD MBA FACP 🇺🇸🇵🇰 Krina Patel MD Anderson Cancer Center Memorial Sloan Kettering Cancer Center #SOHO2024 #SOHO24

Best slide of #SOHO24 goes to Saad Z. Usmani MD MBA FACP 🇺🇸🇵🇰 and the #MMsm team of presenters 🏆 Wish I was there to see it!!

Top Influencers of #BPDCN 👉 Naveen Pemmaraju, MD Manju Sengar Prajwal Dhakal Nitin Jain JIPO Editors hcsm.io/1sxbiOp via Symplur

🚨 AURIGA results in #IMS24 app! After ASCT in #MMsm, 30-mo PFS 83% Dara-R vs 66% R alone. Can’t directly extrapolate to quad induction or MRD- after ASCT, and not powered for PFS… … but as a previously loud cynic of CD38-R maintenance sans RCT data, I am a changed man 🫡

👌Fronline treatment of follicular lymphoma conclusion 😊 #FL ✒️By Hill 🛫#SOHO24 #SOHO2024