Cross-sectional data: Individuals with recent and frequent cannabis use and CUD are disproportionately prone to workplace absenteeism, with a dose-response relationship (mild CUD: aIRR=1.60; 1.24-2.08; moderate: 1.98; 1.50-2.61; severe: 2.87; 2.12-3.88 ajpmonline.org/article/S0749-…

retro chart review: women with untreated bipolar disorder in pregnancy had significantly higher rates of premature delivery and low birth weight compared to women on lamotrigine, lurasidone, and SGAs. No difference was observed between mood stabilizers onlinelibrary.wiley.com/doi/abs/10.111…

SR: While certain human studies suggest an association between rTMS-induced anti-inflammatory effects and improvement in psychopathology, heterogeneity, and underpowered analyses constrain the generalizability of these results …-general-psychiatry.biomedcentral.com/articles/10.11…

10-year follow-up study in individuals with 1st-episode psychosis: Insidious onset and baseline disorganized symptoms were associated with an ↑ risk of treatment resistance. Good premorbid academic adjustment and acute onset were associated with response nature.com/articles/s4153…

Compared to healthy controls, plasma matrix metalloproteinase 9 levels were elevated in poor responders with SCZ at baseline and negatively correlated with both white matter density (temporal gyrus) and the change in cognitive symptoms after treatment nature.com/articles/s4153…

Review: Olanzapine (2.5 mg/d for 12 wks) improved appetite, weight, other nutritional parameters, and quality of life in patients with advanced or metastatic cancer treated with chemotherapy. Mirtazapine (30 mg/d for 8 wks), however, brought no benefits psychiatrist.com/jcp/olanzapine…

small RCT: At 16 weeks, in patients with T2DM and MDD, vilazodone, escitalopram, and vortioxetine lowered HDRS scores and declines in glycemic indices. Other metabolic indicators showed no significant alterations doi.org/10.7759/cureus…

Review: GluN2A (NMDAr. subunit) overexpression impairs structural and functional synaptic plasticity, which contributes to the development of depression. Its inhibition could be a promising target for the development of novel ADs academic.oup.com/ijnp/advance-a…

SR: Anticonvulsants are unlikely to be effective in the treatment of behavioral and psychological symptoms in dementia, although the quality of existing evidence is low sciencedirect.com/science/articl…

cohort study: Patients with ADHD may have impaired emotion induction and emotion regulation capacity, but these deficits are not reversed by stimulant medication doi.org/10.1503/jpn.24…

MA: tDCS had a high effect in improving specific symptoms (SMD= −0.73; −1.09 to −0.37) and general anxiety symptoms (−0.75; −1.23 to −0.26) in OCD, PTSD and anxiety disorders, with effects lasting up to 1 month nature.com/articles/s4139…

cohort study: Ketamine was associated with decreased risk of suicidal ideation vs. other ADs: with HR=0.63; 0.53–0.76 at 1 day – 7 days, to 0.78; 0.69–0.83 at 1 day – 270 days. It was robust among adults >24 years of age with recurrent MDD nature.com/articles/s4139…

RCT: Total schizotypy scores were ↓ in both Omega-3 Only and Omega-3 + CBT groups vs. controls (d=0.56 and 0.47, respectively), and also 3 months after supplementation terminated (d=0.49 and 0.70) academic.oup.com/schizophreniab…

NMA: All SGA-LAIs outperformed placebo in reducing acute symptoms after median follow-up=13 weeks. Most formulations outperformed placebo in the very short-term also (2 weeks or less), regardless of the need for initial oral supplementation sciencedirect.com/science/articl…

OL study: Both IV ketamine and IN esketamine reduced depressive symptoms and suicidal ideation after 4 weeks in TRD. Risk of developing AEs was similar with both treatments. All side effects reported were mild and transient sciencedirect.com/science/articl…

Novel Drug Shows Promise in Preventing Early Alzheimer’s Brain Changes A new study has demonstrated that troriluzole, a novel drug, can prevent early-stage brain changes in a mouse model of Alzheimer’s disease. The research found that troriluzole effectively reduces harmful