Very happy our cautionary tale of GECI expression in the hippocampus is out in eLife - the journal. elifesciences.org/articles/93804 We describe Ca2+ waves though the hippocampus. Mesmerising but artefact of GECI expression. Also a tweet print x.com/tonykellyeu/st…. 1/3

First preprint from our X-ray connectomics team at PSI Paul Scherrer Institut Great collaborative effort with Carles Bosch Manuel Guizar-Sicairos Andreas Schaefer Alexandra Pacureanu and many more

Are you working with in vivo optogenetics? Ever wondered what the impact of shining laser light within the brain in the absence of exogenous opsins has on neuronal activity? PLEASE SEE biorxiv.org/content/10.110… & READ 🧵👇 work done SWC, thx Mateo Velez-Fort & Troy Margrie

Hear hear, Peter Rupprecht applied CASCADE spike inference on calcium imaging with GCaMP8 indicators and the accuracy is much better (: github.com/HelmchenLabSof… gcamp6f.com/2024/08/22/spi… Peter Rupprecht

New blog post on spike inference for GCaMP8 data with Cascade: gcamp6f.com/2024/08/22/spi… The new pretrained models for GCaMP8 are available: github.com/HelmchenLabSof…

Did you ever want to image more than one millimeter deep in the brain? Check out our new preprint: 3P-imaging in mPFC biorxiv.org/cgi/content/sh… #DZNE

We just came back from Bilbao (Ʌʗʜʋʗɑɼɼʘ) where we performed fiber photometry training. We collected nice signals and compared GCaMP6f and jRGECO1a sensors.

Long awaited (thanks James Manton for posting the patent application!) and now out in Science Magazine: Using absorption to look deeper by HongLab - they achieved approx. 3 mm depth using the food dye tartrazine: #Microscopy science.org/doi/10.1126/sc…

🔔🔵After nearly 5 years from its conception with Johannes Bohacek, I'm proud to share that our paper on opto-fMRI of the Locus Coeruleus is finally published in Nature Neuroscience! Huge thanks to everyone who contributed—including reviewers and editors! rdcu.be/dT3kB

One thing that always bothered me with biophysical neuron model was our inability to properly train them on data… we fixed that. Great work by a PhD student team Michael Deistler Kyra Kadhim Jonas Beck Janne Lappalainen Matthijs Pals

Check our new preprint studying the response of individual neurons in the hippocampus after global microstrokes in relation to cognitive decline - doi.org/10.1101/2024.0…!

Super-excited to reveal our latest fluorescent voltage indicator, ASAP5, now online Neuron! ASAP5 features higher responsivity and kinetics, allowing detection of single synaptic transmission events. The link gives free access until 2024.11.09: authors.elsevier.com/a/1joYd3BtfH9B…