A remarkable epigenetic phenomenon known as genomic imprinting was discovered in 1984. Anne Ferguson-Smith and Dr. Marisa Bartolomei trace the history of this field and the impact it has had on scientists’ understanding of development, inheritance and disease. go.nature.com/4dySaHA

Congratulations to Raffaele Teperino on this important work! Keeping the momentum of sperm RNA research going to the next level! Thanks Julian Anna Nowogrodzki for the engaging interview!

Congrats Raffaele Teperino & team on advancing sperm mitochondrial tRNAs/tsRNAs in epigenetic inheritance nature! nature.com/articles/s4158… In our N&V Nature News & Views, we highlight the trade-off between mitochondrial function and the accuracy of 'Sperm RNA code' & more👏 nature.com/articles/d4158…

A father’s fatty diet causes mitochondria in sperm to produce RNAs that affect the child’s health. Qi Chen & Cai Chen from Qi Chen propose that this results from a trade-off between maintaining mitochondria function and RNA information. go.nature.com/3KwJUdP

Honoured to see our study rdcu.be/dJ0ab highlighted by Qi Chen. Thanks a lot Qi!

Adding to the intriguing story of Vault structures & their component Vault RNAs, we highlighted that Vault RNA-derived small RNAs (vtsRNAs) also bear biological functions: nature.com/articles/s4155… It's fascinating to see how nature always repurposes molecules for new functions! ♾

In our new review paper, Yue Wan and I focused on the functional importance of RNA structure in gene regulation. Many thanks to Yue and Xinang! I really enjoy the writing process. nature.com/articles/s4158…

A new chapter for genome editing: RNA-guided recombinase enzymes have been discovered that enable the programmable insertion, inversion or deletion of long DNA sequences go.nature.com/3RHgWMA

What do long noncoding RNAs actually look like? A hodgepodge of twisted #RNA elements on a string? You’d be right. Happy to share new paper on #MALAT1 NatureStructMolBiol led by Ilias Skeparnias w/Bou-Nader lab Dimitrios Anastasakis Markus Hafner Yun-Xing Wang Lab go.nature.com/4eLNyP4

Really proud that our work on embryos and stem cell embryo models led by many talented and passionate team members is featured by The Scientist with quotes from one of my first postdocs, the incredible Karolina Piotrowska and someone I always admired, Tom Fleming.

How does one #tRNA-mimicking mascRNA from #MALAT1 get one CCA tail and is stable, while menRNA from #NEAT1 receives two marking it for decay? We uncover a #riboswitch-like mechanism where menRNA self-destructs by getting seconds.Ilias Skeparnias NatureStructMolBiol go.nature.com/3WcOGmc

It took more than a DECADE... but finally it’s published!!! It started as a CRAZY idea but after tons of hard work we built it: We hijacked the endogenous secretion systems of Toxoplasma gondii, a brain parasite, to deliver active proteins to neurons 👇 nature.com/articles/s4156…

1/9 We show that Human ribosomes have different rRNA sequences, predominantly indels. These include abundant variants such as GGC indels, which form different structures. We visualize variants in single cells and associate them with development and cancer. doi.org/10.1016/j.xgen…

Today in Cell we report evidence for a covalent linkage between small RNAs and N-glycans via acp3U Work by Yixuan (Axe) Xie Peiyuan Chai +collab w/Ben Garcia | HSCRB Excited to accelerate more work related to glycoRNAs in many new contexts. doi.org/10.1016/j.cell…

Big congrats Bruno! Bruno Di Stefano Honored to be part of the team!

Nature is amazing! Congratulations to Max Wilkinson and team on a beautiful study revealing a clever way that bacteria defend against viruses. Check out Max’s posts for more detail! doi.org/10.1126/scienc…

This mass spec-based RNA-seq can serve as a powerful tool to decode the RNome, complementary to Nanopore sequencing, with advantage in De Novo sequencing of highly modified RNAs such as tRNAs & tsRNAs, as illustrated in Nature Cell Biology rdcu.be/cLcrj Exciting times ahead!