We are ready to make a big splash with our new in vivo barcoding 'LoxCode' mice in an updated preprint. With it, we answer a key question in development: how does each cell of the pre-gastrulation mammalian epiblast contribute to organogenesis? 1/n biorxiv.org/content/10.110…

Out today in Science Magazine as part of ZoonomiaProject : our deep dive on evolutionary DELETIONS in conserved regions. Learn about this counter-intuitive source of mammalian innovation! Here's a tweetorial on what these surprisingly missing elements are doing in humans

Folks at #BoG23 and others - I'm recruiting postdocs to my Stockholm and New York teams. Reach out if interested - experimental or computational opportunities in gene expression dosage (talk #39), GWAS+CRISPR+molQTLs, developmental GTEx, etc. science.org/doi/10.1126/sc…

Some big news: I’m absolutely delighted to announce that I will be starting my group this fall in the Computational and Systems Biology Program at Memorial Sloan Kettering Cancer Center in New York City! clareaulab.com 1/

Very excited to see our work on using gene features to identify target GWAS genes out at Nature Genetics

Thank you!!! Honored to be a Tufts GSBS Rosenberg Fellow 🥳 Grateful for the nomination from my program and the endless support from my PI and lab ☺️ Ryan Tewhey Tewhey Lab

This is by far the most convincing regulatory DNA synthetic design paper to date. Congrats to the authors 1/

I'm thrilled to share my thesis work with Barak A Cohen and Mike White! We answer the question: what do you do after measuring all cis-regulatory elements (CREs) in the genome? Our proposed solution: active machine learning. 1/n biorxiv.org/content/10.110…

Had a great time hanging out with the Tewhey Lab ! Thanks Ryan Tewhey and The Jackson Laboratory for hosting us!

After a constructive set of reviews, our single-cell reporter work is OUT nature.com/articles/s4159… Check out the briefing if you want the tldr nature.com/articles/s4159… I am particularly fond of some of the new applications. Mini-update.

Two excellent sets of take-home impressions from Sohini Ramachandran and Ewan Birney on #BoG24. I'm going home excited and inspired by the science presented this week. A few impressions from me 1/

Fantastic scMPRA approach from Jean-Benoît (JB) Lalanne, Samuel Gabriel Regalado & Jay Shendure. Lots of great observations buried in the supplemental too!