One week left to apply to the NeuroCOV #postdoc position in our group Human Technopole #Neurogenomics to study the #neurological #neuropsychiatric complications of #LongCovid from #singlecell #deconvolution to mechanisms in #brain #organoids to #population #registries /1

#showyourstripes for Rare Disease Day Feb 28th!

A major contribution that will have a significant impact on the disease modeling (and not only) field. Congrats!

Yearly reminder that not replying to emails is impolite. Not sure who has normalized this practice among academics, but it is not nice. 🙏

Let me rewrite this for you European Research Council (ERC) - the ERC President Maria Leptin emphasizes what a waste of talent and opportunities it is that so many deserving and outstanding projects and scientists can not get funded due to budget constraints. #noScienceNoFutureforEurope

Great use of cortical #organoids from Giuseppe Testa lab to dissect the effects of copy number variations at 7q11.2 at early stages of development, shedding light on the underlying neurobiology of #Williams Syndrome & #Autism Spectrum Disorder 🧠🧫 science.org/doi/full/10.11…

Excited to share in print our disease modelling of #neurodevelopmental conditions caused by #7q11.23 #CNV, #Williams #WBS and #7Dup syndromes science.org/doi/full/10.11… /1

Very detailed dissection of the cellular and molecular mechanisms underlying Gabriele-de Vries syndrome (associated with YY1 mutations), by Marlene F Pereira Michele Gabriele 🔬🧬📸 Alessandro Vitriolo Giuseppe Testa, based on 2D and 3D patient-derived cell lineages 🧠🧬🧫 biorxiv.org/content/10.110…

excited to share our latest work on the mechanisms of Gabriele-de Vries Syndrome #GADEVS a #neurodevelopmental condition we first described in 2017 biorxiv.org/content/10.110… #RareDiseases /1

Proud to share part of my PhD work at Giuseppe Testa Lab! ⬇️ Highlights on the impact of YY1 mutations throughout #corticogenesis with profound synaptic abnormalities followed by #astrocyte pathology! A big thank you to all, specially Michele Gabriele 🔬🧬📸 Alessandro Vitriolo Veronica Finazzi

A rare, exhaustive molecular dissection of a disorder in physiopathologically relevant lineages

Exciting breakthrough: A new microfluid-based human pluripotent stem cell model now allows researchers to accurately model both the rostral-caudal and the dorsal-ventral features of early human central nervous system development. rdcu.be/dzF73

🫥A disease is "rare" when it affects fewer than 1 in 2000 people. Nowadays, more than 6000 rare diseases are identified, 72% of them are genetic diseases and 1 out of 5 cancers is rare. 🥼 Basic research is crucial to improve the lives of affected patients and their families!

1/n You might recall I posted last wk about #mycoplasma positive PCR test in STEMCELL Technologies mTeSR Plus 5X suppl. We received many worried user emails. We stand by our results, but concluded the mTeSR is PCR-positive but likely not carrying live myco. x.com/jogleeson_ucsd…

ISSCR just started, Giuseppe Testa Lab in the place, and we are already amazed by unpublished interactomic data from Magdalena Gotz depicting MAP1B role in neural stem cells. Martina Pezzali Reinald

Join me and my colleagues from Giuseppe Testa lab at ISSCR We show how to model the amazing journey of interneurons towards cerebral cortex in brain assembloids and how this is disrupted in 7q11.23 CNV syndromes. Wed. July 10, Poster # 576, poster session 18.45-19.45

🧑‍🔬A new multiscale study by our Giuseppe Testa Group reveals how 7q11.23 CNV affects neuronal differentiation and function in Williams-Beuren and 7q microduplication syndromes. 📰Published in Journal of Clinical Investigation humantechnopole.it/en/news/multis…

In the latest episode of The Stem Cell Report podcast, Martin Pera talks with Giuseppe Testa Reinald & Marlene Pereira Human Technopole about their comprehensive review (ow.ly/iqpl50SWQln) on models of neurodevelopment. Listen to the conversation ow.ly/2xzB50SWQeX

Our Giuseppe Testa Reinald & Marlene F Pereira talk with Martin Pera StemCellReports and explore the transition from traditional animal models to advanced human cellular models, organoids, and human/animal chimeras in in neurological disease research👉thestemcellreport.buzzsprout.com/1661578/155711…