The de la Roche group (de la Roche Lab CRUK) have developed "superkiller" CAR-T cells targeting a protein in colorectal & liver cancers. Funding from Cambridge Enterprise and Cancer Research Horizons will test its effectiveness in preparation for clinical trials. 👉cruk.cam.ac.uk/maike-de-la-ro…

Prof Cath Noakes #Ventilate 😷 💙 Roychoudhuri Lab has written a nice blog about this and I recall him discussing it here in Twitter too babraham.ac.uk/blog/reducing-…

Big day today for UK students as they find out where they go to University. Some will be delighted - some will be disappointed. No one has asked me where i went to university since i got my first job. Regardless of where you land you will make your way.

Randy Greaves, says studying in Cambridge on the Science and Innovation at Cancer Research UK Black Leaders in Cancer PhD Scholarship Programme has given him the opportunity to realise a life-long dream. #ChangingTheStoryOfCancer Cambridge University BlackinCancer 👉 zurl.co/T2ay

Synaptic synergy of T cell receptor and interleukin 2 receptor in CD8+ T cells biorxiv.org/content/10.110…

Our new review is out in Cancers MDPI with Megen Wittling Anna Cole Brianna Brammer #KaileyDiatikar Schmitt Lab Paulos Lab Strategies for Improving CAR T Cell Persistence in Solid Tumors mdpi.com/2914846 #mdpicancers via Cancers MDPI

Treg fragility and conversion to effector function seems pretty plausible now…

The legacy of Overacre Lab and Vignali Lab describing Treg cell fragility and its importance in IO continues to deliver!

Great job by KayLee Steiner of my group and VUMC_VCI as an AAI Young Investigator awardee to present her work at the #SIS2024 Southeast Immunology Symposium at UAB Immunology Institute

Congrats to Andrew Patterson for his work using CRISPR screens to find we have vastly underestimated the overlap of Inborn Errors of Immunity and Inborn Errors of Metabolism! Inborn errors of immunometabolism? VUMC_VCI VUMC Research science.org/doi/10.1126/sc…

Immuno-STATS create an immunological synapse to boost both the T cell receptor and IL-2 receptor signaling among the RIGHT T-cells!

Fantastic to have had Charlotte Imianowski in the lab during her #PhD and subsequent brief post-doc, such a big part of my early group Cambridge Pathology, and the force behind three first-authored papers! Happy that she has moved on to a postdoc in the legendary Vignali Lab

Excellent opportunity to work with a fantastic mentor.. and you’d be right next door to Roychoudhuri Lab!

Thanks Gosia!

🥼 Scientists found that Ikzf1 associated with Foxp3 via its exon 5 (IkE5) and that IkE5-deficient #Treg cells highly expressed 🧬 genes that would otherwise be repressed by Foxp3 upon T cell receptor stimulation, including Ifng. Immunity | bit.ly/4fKGLWm

Fantastic opportunity to join an exciting new lab at Cambridge Pathology! #immunology #genetics #cancer

Exciting days ahead for Treg cell therapy globenewswire.com/news-release/2…