Marcin J. Suskiewicz Moritz Hunkeler Shourya S Roy Burman Katherine A Donovan Hojong Yoon Radek Nowak Mikołaj Słabicki 🇺🇦 Fischer Lab DrawImpacts Molecular Cell Harvard Cryo-EM Center for Structural Biology SBGrid: Structural Biology Software Harvard Med BCMP Dana-Farber Cancer Biology Department Dana-Farber Chemical Biology Program Centre for Targeted Protein Degradation Fusion Conferences Last but not least, a paywall-free link to our paper can be found below: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2… 18/18

We know drugs can induce protein #polymerization (BI-3802 - #BCL6). Now we know that BTB containing proteins do that endogenously! Great to have been part of this endeavor: sciencedirect.com/science/articl… And a co-publication of Marcin J. Suskiewicz lab: cell.com/molecular-cell…

Ever wondered how (often) inhibitors degrade their targets? Then you should check out our latest preprint : “Inhibitor-induced supercharging of kinase turnover via endogenous proteolytic circuits”, led by the fantastic natalie_scholes biorxiv.org/content/10.110… explanation 🧵👇

Excited to share our latest preprint on developing the first selective class IIb HDAC #degraders! Thrilled to see the #TPD community growing in Bonn Radek Nowak Christian Steinebach ! Huge congrats to first author Shiyang Shiyang Zhai and the entire team! - go.shr.lc/3LqRQhm

Great to have been part of this project with Finn K. Hansen with Dominika and Jan Gerhartz stellar team. #BonnTPD #HDAC #PROTAC

Thrilled to share our labs latest work, now online Cancer Cell where we used positive-selection CRISPR screening to discover that POU2F3 is regulated by the mSWI/SNF complex cell.com/cancer-cell/fu… 1/

1/8 How can we enrich cells with a defined transcriptional state, but without killing them? Please read on! biorxiv.org/content/10.110…

Exciting double #polymerisation seminars this week! Join us on Thursday, July 25th at 11 am EDT to hear the duo of Jiho Park and Paul Park from Dana-Farber as well as Marcin J. Suskiewicz from CNRS 🌍 talk about homomerising transcription factors. 👉 bit.ly/3OmMRjp

Looking forward to tomorrow polymerization seminar by Jiho Park, Paul Park, Marcin J. Suskiewicz! Join us at 11 am EDT!

Enable Cluster in Frankfurt, PROXIDRUGS and TheraNova invite you to the 1st Symposium on Advances in Therapeutic Approaches taking place on December 5th & 6th at Goethe-Universität. Don't miss out on this opportunity and register now!  HMWK Hessen Fraunhofer-Gesellschaft BMBF

TP53: - Discovered 45 years ago, most cited gene all time - No therapies - 500 million people currently living will die of TP53 mutant cancers without new therapies Our Preprint: - A general strategy for TP53 missense mutant cancers (majority) with prototype small molecules

Congrats everybody, that took a while from the preprint 😅💪 nature.com/articles/s4158…

A new paper from Benjamin Ebert, Nathanael Gray, Eric Fischer, Fischer Lab, Yen-Der Li, Michelle Ma, and Muhammad Murtaza Hassan reports a trans-labeling mechanism “template-assisted covalent modification”, which enables proximity-driven pharmacology rdcu.be/dPzUW

Extremely excited about our next in-person TPD event. If you are in Boston on September 12th - sign up and join us for a half day of science and networking! Registration link: forms.gle/a8p2ALX9n2YDWt…

We are looking for a Scientist to join us in the Fischer lab to work on proteomics-based projects. If you are interested in big data problems and using proteomics as a research tool take a look at the job description and apply now! careers.dana-farber.org/job/8602/scien…

Happy to share the latest tricks of the CalpL protease, which turns out to be a ring nuclease, too. A great team effort by Sophie Binder, Niels Schneberger, Maximilian Schmitz, Christophe. Rouillon and Marianne Engeser. academic.oup.com/nar/article/do…

Great to be part of it at Uniklinik Bonn Rheinische Friedrich-Wilhelms-Universität Bonn. We are taking on yet to be drugged transcription factors important in inflammation. #MolecularGlues #PROXIDRUGS

We are hiring! Looking for a #postdoc to join the team in the Nowak Lab to focus on chemical biology in cells and recombinant systems. Excited about protein degradation, small molecule proximity? get in touch! #TPD #InducedProximity #ChemicalBiology nowak-lab.com

Dr. Laurie Glimcher, CEO of Dana-Farber Cancer Institute, said she would step down next month. Dr. Benjamin Ebert, chair of Dana-Farber’s medical oncology department, will take over on Oct. 1. trib.al/WVBqnUH

Congratulations to Ben Ebert - what an amazing person at the helm of the Dana-Farber Cancer Institute. Go Ben! Dana-Farber