Finally out in Cell! Our map of human prefrontal cortex maturation (ga24-40yrs) across all brain cell types. 🧵

Excited to share our work on human prefrontal cortex, using single nuclei RNA and ATAC to cover development from fetal into adulthood! doi.org/10.1016/j.cell… Great team work with Chuck, twitterless Becca Simmons, Saskia Freytag and @ry_Lister.

(1/12) Very happy to present our multimodal snRNA and scATAC resource charting the gene regulatory changes of the human prefrontal cortex from 22 weeks gestation to 40yrs authors.elsevier.com/sd/article/S00…

Register now for Lorne Genome 2023! Abstract submission is open, oral presentations closing in 3.5 weeks. Great lineup of speakers for an in person meeting. Join us there for science, surf, socialising and wildlife. lornegenome.org

Excited to introduce PHYTOMap, a new method for multiplexed 3D spatial gene expression analysis in WHOLE-MOUNT plant tissue! My first preprint from the Joe Ecker lab at Salk Institute. 1/🧵
biorxiv.org/content/10.110…

PHYTOMap: Multiplexed single-cell 3D spatial gene expression analysis in plant tissue biorxiv.org/cgi/content/sh… #biorxiv_plants

So, what happens if you forcibly methylate the DNA of thousands of promoters in the human genome? Well, it's complicated... In our latest work with ryan lister we find that not all methylated promoters get silenced. Anathema!? Keep reading... 1/8

Very happy to see our study on the large‑scale manipulation of human promoter DNA methylation finally out! As we should expect in biology, the reality of these processes is complex. Great work led by Alex de Mendoza, Trung Nguyen, and Ethan Ford genomebiology.biomedcentral.com/articles/10.11…

Want a simple, efficient & reproducible 96 well plate protoplast transfection protocol for Arabidopsis?

Adil Khan has you covered. Used in our recent work developing gene circuits in plants.

dx.doi.org/10.17504/proto…

biorxiv.org/content/10.110…
nature.com/articles/s4158…

Plant Energy Biology Molecular Sci-UWA UWA Research The Perkins ryan lister Synthetic gene circuits for precise reprogramming of plants #NBTintheNews via UWA uwa.edu.au/news/article/2…

Synthetic memory circuits for stable cell reprogramming in plants go.nature.com/3ONp6zl