YES! Issue #2 is out now (free to read for limited time)! - Safety of gene-edited livestock Prof Alison Van Eenennaam (@BioBeef) - Opinion #CRISPR patents - Up close Arc Institute - A chat with george church - Triplet repeat therapies Triplet Therapeutics - somatic cell imaging Krishanu Saha liebertpub.com/toc/genbio/1/2

Check out our next-generation stem cell (iPSCs)- & CRISPR-based approach to treat dystrophic epidermolysis bullosa. Hot off the press: nature.com/articles/s4146… #cellandgenetherapy #regenerativemedicine #genomeengineering #DEBRA #CIRM

Super excited to share that ENGRAM is out today! ENGRAM cells are programmed to write their histories into the genome, recording the intensity, duration, and order of biological events simultaneously. nature.com/articles/s4158…

How can we cut cost of #CRISPR genome editing cures >10-fold from current ~$3-4 million? A roadmap nature Doudna Lab Fyodor Urnov Innovative Genomics Institute nature.com/articles/s4158…

Check out this great summary of our work "MOBE: A Base Editor That Multitasks without Mix-ups" by The Scientist Aparna Nathan featuring Krishanu Saha Komor Lab 🧑‍🔬🧪UCSD Chem Biochem UC San Diego School of Physical Sciences the-scientist.com/mobe-a-base-ed…

"CRISPR as a standard of medical care" - this is the Innovative Genomics Institute mission as set by our founder, Jennifer Doudna. Dr Melinda Kliegman, our Director of Public Impact, led an extraordinary KOL task force to develop actionable solutions to the key challenge of affordability.

Today in Nature Biotechnology, we describe first-gen click editors (CEs), which couple the advantageous properties of DNA-dependent DNA polymerases and HUH endonucleases with RNA-programmable nickases for precise and versatile human genome editing. 🧬 nature.com/articles/s4158…

Protein design is my new LLM vibe check for biology. Here is a snippet of Llama 3.1 generating a green fluorescent protein. The AlphaFold3-predicted structure of "llamaGFP" is shown below with the full sequence as alt text. It has only 30% sequence identity with wild type avGFP!

Excited to share PROD-ATAC, a single-cell tool to study chromatin perturbations caused by protein-coding variants. PROD-ATAC revealed mechanisms and relationships among oncofusions in 30+ cancer types, generating a global view of the oncogenic landscape. Phenomenal work done by

Delighted to share our latest research published in Cancer Cell Cell. Our study shows that intratumoral administration of IL-21 engineered NK cells resulted in strong and sustained antitumor activity against glioblastoma compared to IL-15 NK cells, which carried significant

Have you ever wondered why some cell lines are easy to edit with CRISPR-mediated gene editing, while others are more difficult? Our paper is now online and offers an interesting answer: nature.com/articles/s4158…

Welcome Dr. Bhargava! New to the UW Madison Department of Biomedical Engineering, assistant professor Aarushi Bhargava is researching the expanding impact of ultrasound technology. engineering.wisc.edu/news/focus-on-…

We've started IND-enabling studies on a small molecule corrector for Rho-associated autosomal dominant retinitis pigmentosa (Rho-adRP). I thought it would be fun to spend some time walking through our approach and why we are excited. Long 🧵1/

Elated that 10 years into the founding of the Delgoffe Lab, I've been officially promoted to Professor of Immunology at University of Pittsburgh Pitt Health Sciences UPMC Hillman Cancer Center! It has been a fun and exciting journey, that could not occurred without my incredible colleagues and trainees. Onward!

1/23 We are excited to announce that our most recent study “In vivo dendritic cell reprogramming for cancer immunotherapy” was published in Science Magazine. science.org/doi/10.1126/sc… Here is a summary of what we discovered!

Apoorva Ramamurthy, Ph.D. student at UW–Madison, represented CMaT at yesterday's Perfect Pitch Competition! There are 15 total participants from various ERCs at the 2024 NSF ERC Biennial Meeting concluding today in Virginia. U.S. National Science Foundation #CMaT

DELIGHTED and GRATEFUL!!! Thank you, ARPA-H, for awarding Cellino up to $25M to develop Nebula, a cassette-based, autonomous tech stack that generates induced pluripotent stem cells in an ultra-scalable manner. We are excited to embark on this technology journey to support

Our final session of the day features professors Kris Saha, Kip Ludwig, Randy Bartels & Colleen Witzenburg discussing how their research transforms healthcare in our community. #UWBME25 Krishanu Saha Cardiovascular Biomechanics Lab

Somatic Cell Genome Editing (SCGE) Outreach Fall meeting in Bethesda. Great opening by Walter J. Koroshetz highlighting some progress over the last year NIH Common Fund #SCGE program with several #FDA meetings to advance #genetherapies. Right now we are hearing advances for #prenatal #geneediting, exciting data.

How can we teach high school students in any geography about the power and magic of CRISPR gene editing? Sarafan ChEM-H Institute Scholar Stanley Qi Lab and affiliate Michael C. Jewett Stanford Engineering developed this affordable kit! nature.com/articles/s4146…