Vacations as an academic

It was great writing this Perspective with my man Dan Squair on the new world of non-lysine ubiquitination. Exciting times! nature.com/articles/s4158… nature.com/articles/s4158…

Evidence of more non-protein Ub substrates (plus some NEDD8 and ISG15 into the mix too) from the Mizushima lab! Mizushima Lab (UTokyo) 👀

This is awesome! They show that protein ADP ribosylation can bridge substrate to ubiquitin via an ester linkage. Also show that RING E3s can contribute directly to catalysis by directing Ub to non lysine sites. science.org/doi/10.1126/sc…

With the unexpected breadth of the ubiquitin system becoming ever more apparent, I'm delighted to have been awarded this 8 year Wellcome Trust Discovery Award to further uncover the potential wonders associated with novel classes of E3 ligase. #E3 #ubiquitin

Yep!

Congrats to Ricardo for cleaning up at the recent Dundee venture awards!

Great visit to TU Wien today. Thank you Anne Conibear MikulaLab Marion Goldeck and Brigitte Holzer for hosting. Looking forward to the Ubiquitin and Friends Symposium tomorrow! #Ubiquitin

Happy 50th birthday to our friend and colleague, Miratul Muqit! We wish you many more years of ground-breaking PINK1 research!

Congratulations in order once again for Ricardo! ppu.mrc.ac.uk/news/ricardo-m…

Very happy to share our work uncovering the mystery of how the giant E3 UBR4 carries out ubiquitination. #ubiquitin #E3ligase nature.com/articles/s4159…

Well done Ricardo! ppu.mrc.ac.uk/news/ricardo-m…

Wise words from Peter Mabbitt at Scion, NZ nature.com/articles/s4159…

It’s UBR4 month! @Rapelab show it is part of a complex that silences mitochondrial stress response pathways and defects cause neurodegenerative disease. With our discovery of the UBR4 E3 module this may open therapeutic possibilities. #ubiquitin #E3ligase nature.com/articles/s4158…

Immensely proud and excited by the launch of Outrun Therapeutics! With our fantastic team, technology and investors, I look forward to the new protein-stabilising medicines Outrun will develop by modulating the ubiquitin system. #ubiquitin #E3ligases linkedin.com/posts/outrun-t…

Great to see our probe chemistry for transthiolation activity being used to structurally track ubiquitin going through a canonical E1-E2-E3 cascade. #ubiquitin nature.com/articles/s4158…

Thank you GCE4ALL Research Center @klang Abhishek Chatterjee for the opportunity to share our work and hear what's happening with genetic code expansion at #GCE2024. And what a finish to the evening! 😎

California dreamin'? No need in September at the University of Dundee!