How do #GPCR and growth factor receptor pathways interact in cells?

Applying #MassSpectometry , a team reveals how EGFR shapes the signaling of #CXCR4 through distinct phosphorylation events that modify the binding properties of G-alpha-i. UC San Diego Skaggs School of Pharmacy scim.ag/7lc

In this week’s Editors’ Choice piece, we highlight the work of Simpson and colleagues in Nature Communications, showing that immature peripheral B cell apoptosis may be due to a lack of survival signals.

Read a summary: scim.ag/7kK

The loss of the protein BAP1 slows the division of #UvealMelanoma cells and enables them to survive poor nutrient conditions, explaining how they survive dissemination during #metastasis . Aplin Lab - Cancer Research Vivian Chua Thomas Jefferson University

Read more: scim.ag/7ks

The putative calcium-sensing protein #MCTP1 drives the neuroendocrine differentiation and maintenance of #ProstateCancer cells through a mechanism involving ZBTB46, FOXA2, and HIF1A, reveal new experiments from a team at Taipei Medical University. scim.ag/7iO

This week’s new issue of #ScienceSignaling has arrived!

A study shows how a putative calcium-sensing protein drives a rare and aggressive prostate cancer, research delineates how uveal melanoma cells survive metastatic journeys, and more. scim.ag/7hP

Combining an array of lab techniques, scientists decipher some of the biochemical events that shape the activity and diversity of signals generated by #GPCRs —offering new insights about these important receptors and drug targets. UC San Diego Skaggs School of Pharmacy scim.ag/7h2

Facing viral infection, mammalian cells can form granules consisting of enzymes that help sense and respond to invading viruses, hinting that these granules act as molecular switches that permit cells to combat viral infections. Wertheim UF Scripps scim.ag/7gc

Scientists find the enigmatic #phosphoinositide PI5P shapes Hippo signaling through a feedback loop involving the kinases MST1/2, which inhibit PI5P4K kinases through #phosphorylation and enable PI5P to interact with MOB1. Brooke Emerling Sanford Burnham Prebys scim.ag/7g1

In this week’s Editors’ Choice piece, we highlight the work of Wei and colleagues in nature, showing that bacterial LPS disrupts the blood-brain barrier in mice by inducing endothelial cell pyroptosis. 

Read a summary: scim.ag/7fi

How do #GPCR and growth factor receptor pathways interact in cells? Applying #MassSpectometry , a team reveals how EGFR shapes the signaling of #CXCR4 through distinct phosphorylation events that modify the binding properties of G-alpha-i. UC San Diego Skaggs School of Pharmacy scim.ag/7df

Scientists find the enigmatic #phosphoinositide PI5P shapes Hippo signaling through a feedback loop involving the kinases MST1/2, which inhibit PI5P4K kinases through #phosphorylation and enable PI5P to interact with MOB1. Brooke Emerling Sanford Burnham Prebys scim.ag/7bw

A recent preclinical study offers insights into how cells can resist #cancer drugs called #MAPKInhibitors and identifies additional molecular players that might be co-targeted to potentiate clinical responses. NCI Center for Cancer Research scim.ag/7aH

Facing viral infection, mammalian cells can form granules consisting of enzymes that help sense and respond to invading viruses, hinting that these granules act as molecular switches that permit cells to combat viral infections. Wertheim UF Scripps scim.ag/7ar

Research this week reveals a connection between the phosphoinositide PI5P and the #HippoSignaling pathway and could inform efforts to define how these molecular players go awry in diseases such as #cancer . Brooke Emerling The Blind Lab Sanford Burnham Prebys scim.ag/79E

In this week’s Editors’ Choice piece, we highlight the work of Irala and colleagues in Neuron, showing that astrocyte-secreted neurocan guides inhibitory circuit formation in the mouse brain. 

Read a summary: scim.ag/797

Scientists find the enigmatic #phosphoinositide PI5P shapes Hippo signaling through a feedback loop involving the kinases MST1/2, which inhibit PI5P4K kinases through #phosphorylation and enable PI5P to interact with MOB1. Brooke Emerling Sanford Burnham Prebys scim.ag/78b

Don’t miss this week’s new issue of #ScienceSignaling !

Experiments show how an enigmatic lipid supports the growth-regulating Hippo signaling pathway, our weekly Editors’ Choice piece connects astrocytes with inhibitory circuits in the brain, and more. scim.ag/77i

Investigators have teased apart a key signaling pathway that sustains the growth and “structural pruning” of #neuron circuits in the brain in mice—establishing a valuable resource for future studies of neuronal gene expression. Philipps-Universität scim.ag/75M

A research team at NCI Center for Cancer Research delineated how the catalytic subunit of PP6 constrains the growth of KRAS- and BRAF-mutant #cancer cells and found that removing the subunit engenders resistance to MAPK inhibitors through #NFkB . scim.ag/75B