The brain may use #dopamine to help degrade #amyloidbeta, a protein linked to neurodegenerative disorders, according to a new preclinical study that also reveals how this “self-cleanup” process goes awry in #AlzheimersDisease. RIKEN scim.ag/84e

Researchers find that blocking #CellStress during protein synthesis may protect neurons in patients with neurodegenerative disorders such as amyotrophic lateral sclerosis (#ALS) and frontotemporal dementia (#FTD). Shuying Sun Bin Wu Lab Physiology Department JHMI scim.ag/84N

Examining #AT1R, a team finds natural and synthetic ligands activate G proteins and/or #BetaArrestin according to distinct #phosphorylation patterns, lending support to the popular “barcode” hypothesis in #GPCRSignaling. Howard Rockman Duke Department of Medicine scim.ag/853

This week in #ScienceSignaling: Scientists show how dangerous coronaviruses use a host protease to invade and replicate within cells, the Editors’ Choice piece examines research about a connection between inflammasome activation and stroke, and more. scim.ag/85N

Coronaviruses such as #SARSCoV2 and #MERSCoV exploit the host protease #KLK5 to cleave both priming and activation sites on spike proteins in order to enter cells, suggesting that KLK5 is a pancoronavirus host factor and therapeutic target. IBS_media(기초과학연구원) scim.ag/87L

In this week’s Editors’ Choice piece, we highlight the work of Cao and colleagues in nature, showing how inflammasome activation by circulating DNA can lead to stroke. Read a summary: scim.ag/87P

Examining #AT1R, a team finds natural and synthetic ligands activate G proteins and/or #BetaArrestin according to distinct #phosphorylation patterns, lending support to the popular “barcode” hypothesis in #GPCRSignaling. Howard Rockman Duke Department of Medicine scim.ag/88b

The brain may use #dopamine to help degrade #amyloidbeta, a protein linked to neurodegenerative disorders, according to a recent preclinical study that also reveals how this “self-cleanup” process goes awry in #AlzheimersDisease. RIKEN scim.ag/88l

Scientists show the host enzyme KLK5 enables coronaviruses to invade and replicate within airway cells, but also find that the plant-derived compound ursolic acid can target KLK5 to suppress viral replication and lung inflammation in mice. IBS_media(기초과학연구원) scim.ag/88P

Don’t miss this week’s issue of #ScienceSignaling! Researchers discover a potential drug target plays important roles in B cell migration, a study demystifies how the virus HCMV establishes stealthy, long-lived infections in immune cells, and more. scim.ag/89X

Scientists interrogate early biochemical events in #CXCL13 signaling in #Bcells, which induces cytoskeletal changes enabling cell migration, and discover that they are mediated by the kinase #WNK1. NIAID News scim.ag/8bS

In this week’s Editors’ Choice piece, we highlight the work of Zhu and colleagues in Cell Metabolism, showing that the proliferation of somatic clones deficient in PKD1 prevents fatty liver disease without causing tumors. scim.ag/8cI

Coronaviruses such as #SARSCoV2 and #MERSCoV exploit the host protease KLK5 to cleave both priming and activation sites on spike proteins in order to enter cells, suggesting that KLK5 is a pancoronavirus host factor and therapeutic target. IBS_media(기초과학연구원) scim.ag/8db

Researchers find that blocking #CellStress during protein synthesis may protect neurons in patients with neurodegenerative disorders such as amyotrophic lateral sclerosis and frontotemporal dementia. Shuying Sun Bin Wu Lab Physiology Department JHMI #ALS scim.ag/8dn

A new preclinical study shows that the protein #WNK1—a potential drug target in #cancer and hypertension—also plays important roles in humoral #immunity and #Bcell migration, suggesting scientists should develop WNK1 inhibitors with caution. NIAID News scim.ag/8dS

In a new study, researchers reveal how human cytomegalovirus persists in its hosts by manipulating pathways in infected monocytes, a finding that could inform investigations into new #antiviral targets. Upstate Medical University #Immunology scim.ag/8e7

This week, scientists determine #CrystalStructures of the kinase #GSK3beta bound to native phosphoprimed or phosphomimetic #BetaCatenin and find the latter reacts more slowly despite having an indistinguishable structure. Stanford Medicine scim.ag/8fT

In this week’s Editors’ Choice piece, we highlight the work of Eberle and Gustavsson in Structure, showing that anionic lipid bilayers enhance the interaction between CXCL12 and the atypical chemokine receptor ACKR3. Read a summary: scim.ag/8gu

How does human cytomegalovirus establish quiescent infections in monocytes? A new study discovers that the virus delivers the protein US28 to monocytes to limit activation of the host kinase Akt, ensuring the survival of the infected cells. scim.ag/8h6