Science Signaling
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Uncovering mechanisms in biology, gaining insights into physiology and disease.
ID: 137777298
https://www.science.org/journal/signaling 27-04-2010 18:46:45
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Researchers find that blocking #CellStress during protein synthesis may protect neurons in patients with neurodegenerative disorders such as amyotrophic lateral sclerosis (#ALS) and frontotemporal dementia (#FTD). Shuying Sun Bin Wu Lab Physiology Department JHMI scim.ag/84N
Examining #AT1R, a team finds natural and synthetic ligands activate G proteins and/or #BetaArrestin according to distinct #phosphorylation patterns, lending support to the popular “barcode” hypothesis in #GPCRSignaling. Howard Rockman Duke Department of Medicine scim.ag/853
Coronaviruses such as #SARSCoV2 and #MERSCoV exploit the host protease #KLK5 to cleave both priming and activation sites on spike proteins in order to enter cells, suggesting that KLK5 is a pancoronavirus host factor and therapeutic target. IBS_media(기초과학연구원) scim.ag/87L
Examining #AT1R, a team finds natural and synthetic ligands activate G proteins and/or #BetaArrestin according to distinct #phosphorylation patterns, lending support to the popular “barcode” hypothesis in #GPCRSignaling. Howard Rockman Duke Department of Medicine scim.ag/88b
Scientists show the host enzyme KLK5 enables coronaviruses to invade and replicate within airway cells, but also find that the plant-derived compound ursolic acid can target KLK5 to suppress viral replication and lung inflammation in mice. IBS_media(기초과학연구원) scim.ag/88P
Scientists interrogate early biochemical events in #CXCL13 signaling in #Bcells, which induces cytoskeletal changes enabling cell migration, and discover that they are mediated by the kinase #WNK1. NIAID News scim.ag/8bS
In this week’s Editors’ Choice piece, we highlight the work of Zhu and colleagues in Cell Metabolism, showing that the proliferation of somatic clones deficient in PKD1 prevents fatty liver disease without causing tumors. scim.ag/8cI
Coronaviruses such as #SARSCoV2 and #MERSCoV exploit the host protease KLK5 to cleave both priming and activation sites on spike proteins in order to enter cells, suggesting that KLK5 is a pancoronavirus host factor and therapeutic target. IBS_media(기초과학연구원) scim.ag/8db
Researchers find that blocking #CellStress during protein synthesis may protect neurons in patients with neurodegenerative disorders such as amyotrophic lateral sclerosis and frontotemporal dementia. Shuying Sun Bin Wu Lab Physiology Department JHMI #ALS scim.ag/8dn
A new preclinical study shows that the protein #WNK1—a potential drug target in #cancer and hypertension—also plays important roles in humoral #immunity and #Bcell migration, suggesting scientists should develop WNK1 inhibitors with caution. NIAID News scim.ag/8dS
In a new study, researchers reveal how human cytomegalovirus persists in its hosts by manipulating pathways in infected monocytes, a finding that could inform investigations into new #antiviral targets. Upstate Medical University #Immunology scim.ag/8e7
This week, scientists determine #CrystalStructures of the kinase #GSK3beta bound to native phosphoprimed or phosphomimetic #BetaCatenin and find the latter reacts more slowly despite having an indistinguishable structure. Stanford Medicine scim.ag/8fT