Our ICLR paper describing a new method for ML-guided protein design has been featured on MIT news!

Best buds (Mount Tom, MA)

Mount Tom, MA

Extensive research has shown that the two best postures for reading papers are (1) laying on the grass on a sunny day, paper stack between face and sun and (2) goblin focus-mode slav squat at the darkest corner of the bar

With Oded Rechavi Shahar Bracha and colleagues we present the revolutionary idea of using brain parasites as brain therapy delivery vehicles and demonstrate the feasibility of the first few steps. Watch: m.youtube.com/watch?v=M9VoVh… Read: nature.com/articles/s4156…

It took more than a DECADE... but finally it’s published!!! It started as a CRAZY idea but after tons of hard work we built it: We hijacked the endogenous secretion systems of Toxoplasma gondii, a brain parasite, to deliver active proteins to neurons 👇 nature.com/articles/s4156…

Researchers have taken the first steps toward making a brain parasite into a delivery vehicle for drugs and helpful proteins. sciencenews.org/article/toxopl…

Oded Rechavi Renaud Jolivet Baller move:

I think there is also an important lesson here on the vast untapped potential that lies in expanding synthetic biology beyond model organisms. Thank you datree.io for emphasizing my musing about this in his piece fiercebiotech.com/research/resea…

Could my favorite parasite be used to deliver drugs to the brain? Sounds like science fiction, but a new study led by Shahar Bracha takes a big leap towards this idea. Read my latest in The Conversation U.S. to learn more. theconversation.com/a-common-paras…

A parasite that can be transmitted to humans through cat faeces or undercooked meat can deliver therapeutic proteins to the brain go.nature.com/4dyeEYr

Repurposing toxoplasma as a delivery vehicle to the brain! Demoed with a delivery of MeCP2 - a Rett Syndrome therapeutic target - to mouse brains via intraperitoneal T gondii injection Led by Oded Rechavi lab, Shahar Bracha