In a Review now published online, Yi Pu, Lu Li, Haoning Peng, Lunxu Liu, Dominique Heymann, Caroline Robert, François Vallette & Shensi Shen define drug-tolerant persister cells, discussing their dynamic phenotypes & their role in resistance to treatment nature.com/articles/s4157…

Finally! Thanks to NatureRevClinOncol gave us this great opportunity! Great cooperation between researchers from China & France. Keen to translate #persister cells from bench to bedside rdcu.be/dmW66

New! Online now: CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression dlvr.it/SxZByH

Tarlatamab (DLL3 x CD3) for Patients with Previously Treated Small-Cell Lung Cancer | NEJM $AMGN #ESMO23 "Positivity for DLL3 expression was not required" OS >12mo in hard-to-treat cancer 1 related death (respiratory failure) 100mg more complex to manage nejm.org/doi/full/10.10…

Bravo Laura !

Applied mathematics isn't just about modelling. In our latest research case study, Joshua Bull and Helen Byrne used a suite of mathematical tools to describe the spatial interactions between different cell types in complex images of COVID-19 lungs. maths.ox.ac.uk/node/66152

Online Now: Genomic alterations driving precancerous to cancerous lesions in esophageal cancer development dlvr.it/SzXrS4

Antibody-drug conjugates to treat cancer continue to drive deals, with J&J's announcement today of its acquisition of Ambrx for $2 billion #JPM24 Here's a recent comprehensive review of the ADC field bit.ly/43BKDm6 rdcu.be/dvr6k

Don't forget - MRS ECRs interested in attending the EACR meeting on "The Tumour Ecosystem: Cellular Interactions & Therapeutic Opportunities" can apply for a travel fellowship | → eacr.org/conference/tum… ← | Deadline 31st Jan so be quick

Start 2024 with an official visit to Gustave Roussy by the delegations of WCH

While hypothesizing about "AI in drug discovery revolution" guarantees to make the news nowadays, a different type of treatment is truly (& more discretely) revolutionizing the cancer standard of care as unseen in decades. Antibody-drug conjugates: the "biological missiles"🎯

In-depth genomic analysis of SCLC demonstrates that treatment-naive tumors show clonal homogeneity, but chemotherapy triggers significant genetic diversity. Effective first-line treatment is crucial in SCLC, as it shapes the genomic landscape of relapse & resistance

This building is nearly 2,000 years old. How can something so ancient, of such scale, still be standing? The answer might surprise you... (thread) 🧵

Stunning Bergamo，and very inspiring EACR TUMOR ecosystem conference.

Cancer is a complex disease Cell Press cell.com/cell/fulltext/…

Our first touch, in collab with clinician Lun-xu Liu — Multicellular ecotypes shape progression of LUAD: a vision from radiological patterns online today Cell Reports Medicine We revealed that neoantigens can be presented at very early stage (pre-cancerous) LUAD. sciencedirect.com/science/articl…

Congratulations to the Der Lab at UNC RAScals for their back to back Science Magazine papers today Channing Der Jennifer Klomp Clint Stalnecker Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers science.org/doi/10.1126/sc… Determining the ERK-regulated phosphoproteome

⚡️🔬📣 Excited to share our new nature article building and evaluating PathChat, a multimodal generative AI copilot and chatbot for human pathology. Article: nature.com/articles/s4158… Open Access Link: rdcu.be/dKC0r We leverage our previous success in building

A single-molecule nanopore sequencing platform from BGI/MGI. No data available. biorxiv.org/content/10.110…

Honored to be part of this beautiful work led by mariangela russo & Bardelli Lab Avant-premier avec Nature Reviews Cancer