🔺#Microbiome composition 🔗to #IBD Location (ileal vs colonic CD/UC vs L3CD) 🔺TNFi (but not VDZ or UST) shift microbiome composition, ⬇️ dysbiosis, ⬆️load 🔺TNFi > VDZ in pts w Bacteroides2 ✅Predictive model of Rx response👇🏽 Gastroenterology doi.org/10.1053/j.gast…

OUT NOW: A model based on microbial community metabolomics reveals insights into community assembly and resource competition in vitro by Kc Huang, Taylor Nguyen & co Stanford University nature.com/articles/s4156…

Opposing diet, #microbiome & metabolite mechanisms in IBD. Combo of genetics, reduced dietary fiber &mucin-degrading bacteria triggers IBD. Mucus loss promotes Th1 that drives #colitis. Fiber-free exclusive enteral nutrition prevents colitis Eric C Martens cell.com/cell-host-micr…

Ever wonder how microbes interact with the host at a molecular level? Check out our latest paper in @nature with Noah Palm and Curtis Huttenhower where we developed a host:microbe profiling technology, BASEHIT, to atlas interactions between commensal microbes and the human exoproteome.

A gut-derived hormone regulates cholesterol metabolism: Cell. Wow cell.com/cell/abstract/…

Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria in ⁦Cell⁩ by ⁦Xavier Lab⁩ cell.com/cell/abstract/…

So happy to share my PhD work published today nature ! We studied how tissue niches shape Treg function. So grateful to Fiona The Powrie Lab, Emily Dr Emily Thornton and a wonderful collaboration with Sarah Teichlab and Raquel Raquel Bartolomé-Casado. We did it! nature.com/articles/s4158…

Integrating research on bacterial pathogens and commensals to fight infections—an ecological perspective - The Lancet Microbe thelancet.com/journals/lanmi…

Fecal microbiota transplantation for recurrent C. difficile infection can be the best therapeutic option in severely immunocompromised patients depending on a case-by-case assessment of the benefit/risk ratio ⁦Gastroenterology⁩ sciencedirect.com/science/articl…

Congratulations Anna Weiß for winning a VAAM PhD Award VAAM - Vereinigung f. Allg. u. Ang. Mikrobiologie 2024 for her outstanding PhD thesis! Wonderful opening of this year's dghm-vaam.de conference in Würzburg #DGHMVAAM #proudpi Microbiome Signatures

Response, resistance, and recovery of #gut #bacteria to human-targeted drug exposure. Maier_Lab reviews how gut commensals respond to drug exposure, both as single organisms or as a community, with a particular focus on human-targeted drugs. cell.com/cell-host-micr…

📢OPEN PhD POSITION📢 Looking for a PhD and interested in the emerging field of mucosal immunology? Apply now to join our young and enthusiastic team in using new tools to understand how T cells are primed by gut microbes and how they become dysregulated in IBD! Please retweet!

Made it to Rome for #IHMC 2024! Looking forward to four days of microbiome science and pizza 🍕 Hit me up at poster 608 if you want to learn how microbiome evolution can protect us from enteric infection!

As an e-poster presenter at #IHMC 2024 I couldn‘t agree more!

Disease-adapted bacterial lineages in IBD. New work by Smillie lab Harvard Medical School studies evolution of gut bacteria across thousands of stool metagenomes & discovers hundreds of lineages adapted to inflammatory conditions & predictive of disease severity cell.com/cell-host-micr…

New review out in Science Magazine from Jacob Wilde and Kevin Foster, that I had the honor to meddle in as the resident immunologist. What possibilities do hosts have to influence their microbiomes? May contain pandas... Enjoy! science.org/doi/10.1126/sc…

Excited to announce our latest publication. In collaboration with the Terzić lab at the University of Split, we discovered that the gut microbiota metabolizes organic carcinogens, leading to altered toxicokinetics and increased bladder cancer incidence. nature.com/articles/s4158…

Wow - autoantibodies against IL-10 seen in Inflammatory Bowel Disease 🤯 Neutralizing Autoantibodies against Interleukin-10 and B cell depletion was effective to treat the disease Understanding the cause enables #personalizedmedicine in #IBD nejm.org/doi/full/10.10…

Engineered probiotic ameliorates ulcerative colitis by restoring gut microbiota and redox homeostasis Cell Host & Microbe cell.com/cell-host-micr…